{"id":"W2602728909","doi":"10.1200/jco.2013.31.15_suppl.7116","title":"A phase II study of mocetinostat, an oral isotype-selective histone deacetylase (HDAC) inhibitor, in combination with 5-azacitidine in patients with myelodysplastic syndrome (MDS).","year":2013,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pyrogenesis (Canada)","funders":"","keywords":"Medicine; Azacitidine; Decitabine; Myelodysplastic syndromes; Lenalidomide; Internal medicine; Pharmacodynamics; Cytarabine; Gastroenterology; Phases of clinical research; Oncology; Bone marrow; Pharmacokinetics; Leukemia; Multiple myeloma; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001540308,0.001725832,0.002315202,0.0004972078,0.000443382,0.001135107,0.001014738,0.001377065,0.00339362],"category_scores_gemma":[0.00098853,0.0009287436,0.001244921,0.0004437909,0.001352969,0.001107313,0.0004170104,0.003802185,0.0008389825],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009010784,"about_ca_system_score_gemma":0.001544932,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009579609,"about_ca_topic_score_gemma":0.002206737,"domain_scores_codex":[0.9995164,0.0002324895,0.00002496158,0.00009102521,0.00003791833,0.00009737847],"domain_scores_gemma":[0.9991898,0.0001351363,0.0001302113,0.00005940894,0.00004111129,0.0004443569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.728948,0.1418938,0.008225149,0.0008808942,0.001297528,0.0005895877,0.0004947879,0.002254335,0.04077721,0.0003382724,0.003280631,0.07101985],"study_design_scores_gemma":[0.5868477,0.4002807,0.007638338,0.0000258783,0.0002922135,0.0002699221,0.00006644257,0.0008452343,0.00191756,0.0001227229,0.001669684,0.00002362465],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993566,0.001657959,0.0004263384,0.0004022154,0.0001348865,0.002028945,0.0005926047,0.00005594252,0.001135124],"genre_scores_gemma":[0.9895404,0.001881532,0.001399064,0.0008081812,0.000244982,0.002183815,0.001707879,0.00002343095,0.002210748],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00339362,"threshold_uncertainty_score":0.01135278,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02989763569009208,"score_gpt":0.3943518609295845,"score_spread":0.3644542252394924,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}