{"id":"W2602918057","doi":"10.1200/jco.2013.31.15_suppl.9029","title":"Preliminary results from a phase Ib/II, open-label, dose-escalation study of the oral BRAF inhibitor LGX818 in combination with the oral MEK1/2 inhibitor MEK162 in <i>BRAF</i> V600-dependent advanced solid tumors.","year":2013,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"","keywords":"Medicine; MEK inhibitor; Internal medicine; Nausea; Adverse effect; Melanoma; Oncology; Cancer; Gastroenterology; Colorectal cancer; Pharmacology; Cancer research; MAPK/ERK pathway; Kinase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002969485,0.000228331,0.000979416,0.0000842548,0.00009491513,0.00003347371,0.0007676582,0.0003774472,0.00001734058],"category_scores_gemma":[0.001470458,0.00012964,0.0001159206,0.0002270073,0.0001989627,0.00006721203,0.0005415994,0.0008080389,0.00000298154],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007156323,"about_ca_system_score_gemma":0.0006965295,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003105839,"about_ca_topic_score_gemma":0.002312604,"domain_scores_codex":[0.9949095,0.001436365,0.002531461,0.0004078377,0.0004361853,0.000278715],"domain_scores_gemma":[0.9961171,0.0005471774,0.002335936,0.0004603121,0.0003979886,0.0001414504],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.1291108,0.1026207,0.05671073,0.00004735726,0.0007520793,0.0005155971,0.004339742,0.00159691,0.4674077,0.00009410077,0.01527102,0.2215333],"study_design_scores_gemma":[0.2772828,0.2942743,0.3475105,0.0004931377,0.0003606821,0.0001727387,0.004520745,0.00131524,0.06275786,0.0009594557,0.009577157,0.0007753649],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947907,0.0001108936,0.00003727478,0.002677031,0.0007273452,0.001339659,0.00002546452,0.000003379348,0.0002882372],"genre_scores_gemma":[0.9982183,0.00004468331,0.000546595,0.0005821531,0.0003650136,0.00005230891,0.00002945968,0.00002258144,0.0001388996],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4046499,"threshold_uncertainty_score":0.5286564,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06499674081682533,"score_gpt":0.3997481824661296,"score_spread":0.3347514416493043,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}