{"id":"W2602918057","doi":"10.1200/jco.2013.31.15_suppl.9029","title":"Preliminary results from a phase Ib/II, open-label, dose-escalation study of the oral BRAF inhibitor LGX818 in combination with the oral MEK1/2 inhibitor MEK162 in <i>BRAF</i> V600-dependent advanced solid tumors.","year":2013,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"","keywords":"Medicine; MEK inhibitor; Internal medicine; Nausea; Adverse effect; Melanoma; Oncology; Cancer; Gastroenterology; Colorectal cancer; Pharmacology; Cancer research; MAPK/ERK pathway; Kinase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002385281,0.001784122,0.001698184,0.0003967444,0.0004644547,0.0009523333,0.001047315,0.001375989,0.003972553],"category_scores_gemma":[0.001530388,0.000691978,0.001191513,0.0003990493,0.0008733756,0.0009894921,0.0003264199,0.003454623,0.0009578793],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008225968,"about_ca_system_score_gemma":0.001660316,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001726413,"about_ca_topic_score_gemma":0.004160096,"domain_scores_codex":[0.9992768,0.0003988124,0.00003952421,0.0000846229,0.00008100658,0.000119189],"domain_scores_gemma":[0.9987586,0.0003472432,0.0001981565,0.0001029893,0.00008695057,0.0005061579],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4277543,0.2267379,0.01150037,0.001597884,0.002357209,0.001070715,0.001122804,0.009200919,0.151632,0.000509455,0.01525207,0.1512645],"study_design_scores_gemma":[0.2659154,0.6889564,0.02078814,0.00005485363,0.0007168861,0.00091999,0.0001262451,0.002517313,0.01259961,0.0004107969,0.006934212,0.00006020995],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.982317,0.002027573,0.002784461,0.001003449,0.0001464534,0.005309488,0.002920992,0.000237954,0.003252623],"genre_scores_gemma":[0.9713846,0.002540914,0.007588239,0.001781157,0.0001638196,0.004705311,0.006675801,0.0001327272,0.005027437],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003972553,"threshold_uncertainty_score":0.01328951,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06499674081682533,"score_gpt":0.3997481824661296,"score_spread":0.3347514416493043,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}