{"id":"W2602964054","doi":"10.1101/119677","title":"Conserved roles of RECQ-like helicases Sgs1 and BLM in preventing R-loop associated genome instability","year":2017,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Canada's Michael Smith Genome Sciences Centre; Université Laval; Pacific Centre for Reproductive Medicine; Terry Fox Research Institute; BC Cancer Agency","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Helicase; Biology; Genome instability; DNA replication; Genetics; RecQ helicase; RNA Helicase A; Minichromosome maintenance; Control of chromosome duplication; Gene; DNA; Cell biology; DNA damage; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000255331,0.0003042215,0.0002433277,0.0002655954,0.0001314637,0.0003428485,0.0002435805,0.0003368415,0.0008469679],"category_scores_gemma":[0.0001860289,0.0001275908,0.0002349109,0.000112459,0.0003549669,0.0002295395,0.0002534184,0.0003138485,0.0003960398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003422967,"about_ca_system_score_gemma":0.0001706346,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002202421,"about_ca_topic_score_gemma":0.0001978495,"domain_scores_codex":[0.9998719,0.00002731826,0.00001284472,0.00003380053,0.00003316236,0.00002095949],"domain_scores_gemma":[0.9998453,0.0000232434,0.0000598052,0.00002251689,0.00001397898,0.00003513279],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001416832,0.00001288102,0.0005788644,0.00002762777,0.000004335225,0.00005971236,0.00000968616,0.0001059219,0.9975185,0.000202597,0.00003506397,0.001303239],"study_design_scores_gemma":[0.00001796613,0.0001189634,0.01000747,0.000004004446,0.000007088305,0.0003637383,0.00002205312,0.0009755976,0.9870771,0.0001720217,0.00123034,0.000003646006],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919625,0.00247284,0.004144088,0.0001601962,0.00001455468,0.0000102273,0.0002513328,0.0001534321,0.0008309354],"genre_scores_gemma":[0.9968489,0.0002540692,0.001692346,0.00002851222,0.000003735914,0.000006105,0.0002099044,0.00001896545,0.0009374297],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008469679,"threshold_uncertainty_score":0.002833426,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01606536920296037,"score_gpt":0.2340765508130925,"score_spread":0.2180111816101321,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}