{"id":"W2603194836","doi":"10.1038/nchembio.2358","title":"Structural and functional insight into human O-GlcNAcase","year":2017,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":99,"is_retracted":false,"has_abstract":false,"ca_institutions":"Simon Fraser University","funders":"Biotechnology and Biological Sciences Research Council; Canadian Institutes of Health Research; Directorate for Biological Sciences; Genome British Columbia; Michael Smith Health Research BC; Diamond Light Source; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Fondation Brain Canada","keywords":"Hydrolase; Dimer; Enzyme; Structural biology; Transferase; Blueprint; Chemistry; Protein structure; Biochemistry; Biology; Cell biology; Stereochemistry; Computational biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000124429,0.0004191963,0.0001900942,0.0001672974,0.0001317756,0.0003710404,0.0002621701,0.0003866719,0.001098766],"category_scores_gemma":[0.00009945205,0.0001629055,0.0002950077,0.0002177152,0.0002341793,0.0003453958,0.0001357383,0.0005961964,0.0004913777],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003489803,"about_ca_system_score_gemma":0.0003877418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008919401,"about_ca_topic_score_gemma":0.0007795295,"domain_scores_codex":[0.9999677,0.000004490198,0.00000302643,0.00000804809,0.000007377304,0.000009446357],"domain_scores_gemma":[0.9999468,0.00001212529,0.000008598432,0.000007962039,0.000007906371,0.0000166687],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005136525,0.00008905356,0.001132157,0.00009722097,0.00001685124,0.000764599,0.00007390647,0.001340943,0.9812949,0.004287601,0.0005426984,0.009846531],"study_design_scores_gemma":[0.00004846251,0.0006975651,0.01218758,0.00002172986,0.00006662585,0.003280194,0.0002381263,0.008162843,0.9347527,0.004729289,0.03578768,0.00002719393],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9720658,0.00489297,0.01450468,0.001589318,0.0001266483,0.00003851653,0.001116361,0.0001719127,0.005493856],"genre_scores_gemma":[0.9773582,0.005196418,0.008407425,0.0004461298,0.00008484731,0.00001438816,0.003128233,0.0000289881,0.005335324],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001098766,"threshold_uncertainty_score":0.003675699,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01512965195910326,"score_gpt":0.3217142540653631,"score_spread":0.3065846021062598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}