{"id":"W2603204749","doi":"10.1016/j.celrep.2017.02.033","title":"Integrative Genomic Analysis of Cholangiocarcinoma Identifies Distinct IDH-Mutant Molecular Profiles","year":2017,"lang":"en","type":"article","venue":"Cell Reports","topic":"Cholangiocarcinoma and Gallbladder Cancer Studies","field":"Medicine","cited_by":612,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; BC Cancer Agency; University of Calgary","funders":"National Human Genome Research Institute; Institute of Chemistry, Chinese Academy of Sciences; National Cancer Institute; National Institutes of Health; Novo Nordisk Fonden; National Institute of General Medical Sciences; Sapienza Università di Roma; Cholangiocarcinoma Foundation","keywords":"Biology; DNA methylation; ARID1A; Mutant; Mitochondrial DNA; Cancer research; Intrahepatic Cholangiocarcinoma; Genetics; Gene; Molecular biology; Mutation; Gene expression; Pathology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001577964,0.0001488855,0.000179458,0.001065812,0.0001567842,0.0002728033,0.0001069047,0.00008743611,0.0006540375],"category_scores_gemma":[0.0002594965,0.00007860951,0.0001650259,0.0005212704,0.0001470353,0.00007482788,0.0003002494,0.0001275394,0.0001097896],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001722783,"about_ca_system_score_gemma":0.0001592932,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008468021,"about_ca_topic_score_gemma":0.002177808,"domain_scores_codex":[0.9998932,0.00001553773,0.000009691863,0.00003405405,0.00002750737,0.0000200064],"domain_scores_gemma":[0.9998922,0.00002335604,0.00003502711,0.00001714765,0.00001292767,0.00001935959],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003861269,0.00002694576,0.1998897,0.00008748345,0.0001192998,0.0006088943,0.0002356496,0.0002822023,0.7761598,0.0004073751,0.0001216837,0.02167486],"study_design_scores_gemma":[0.00001367379,0.0001714606,0.8892462,0.00001129361,0.0001829066,0.003978217,0.0003507162,0.002094257,0.1005645,0.0004558246,0.002918178,0.00001292348],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966859,0.0005747634,0.001628816,0.00002496212,0.000002887407,0.000008871873,0.0004248774,0.00003018375,0.0006187432],"genre_scores_gemma":[0.9973876,0.0002540823,0.001529184,0.00001307922,0.000002680409,0.000007597958,0.0006217211,0.000008140402,0.0001759762],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001065812,"threshold_uncertainty_score":0.002187967,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01650467524406299,"score_gpt":0.2790310838080121,"score_spread":0.2625264085639492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}