{"id":"W2603206028","doi":"10.1007/s00204-017-1942-9","title":"Initial autophagic protection switches to disruption of autophagic flux by lysosomal instability during cadmium stress accrual in renal NRK-52E cells","year":2017,"lang":"en","type":"article","venue":"Archives of Toxicology","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":76,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Consejo Nacional de Ciencia y Tecnología; Deutsche Forschungsgemeinschaft; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Max Kade Foundation","keywords":"Autophagy; Cell biology; Flux (metallurgy); Accrual; Instability; Genome instability; Stress (linguistics); Chemistry; Biology; DNA damage; Apoptosis; Business; Mechanics; Physics; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001613542,0.0002104297,0.0005491151,0.0002520774,0.000144904,0.00001304021,0.000305066,0.0001600765,0.0001397019],"category_scores_gemma":[0.0001958333,0.0001995688,0.000151439,0.0000761998,0.0004405956,0.0001620645,0.0001895497,0.000292849,0.000009330316],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006196518,"about_ca_system_score_gemma":0.0001793714,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001916044,"about_ca_topic_score_gemma":0.000133528,"domain_scores_codex":[0.9982865,0.0001515002,0.0005707999,0.0004169834,0.0002121491,0.0003620892],"domain_scores_gemma":[0.9987121,0.00008726022,0.0003649518,0.0006202125,0.0000366172,0.0001788305],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002562134,0.001023875,0.01672492,0.0002893643,0.00008436189,0.00005440521,0.001381347,0.00007308891,0.9707838,0.0001042856,0.000009527219,0.006908882],"study_design_scores_gemma":[0.001761705,0.0007102519,0.4496185,0.00009053659,0.00002825108,0.00001156578,0.00007236723,0.0001670726,0.5468725,0.0005528748,0.00002296975,0.00009134202],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968165,0.00009562325,0.0001703304,0.0004917278,0.0002333867,0.0009203589,0.0001016132,0.00003623462,0.001134253],"genre_scores_gemma":[0.9991193,0.00001660693,0.0003117016,0.00006000181,0.0001374836,0.00009095965,0.00002540327,0.00002175743,0.0002167964],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4328936,"threshold_uncertainty_score":0.813818,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02067055312981243,"score_gpt":0.311408152488714,"score_spread":0.2907375993589016,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}