{"id":"W2603288306","doi":"10.4049/jimmunol.1601298","title":"Tim-3 is a Marker of Plasmacytoid Dendritic Cell Dysfunction during HIV Infection and Is Associated with the Recruitment of IRF7 and p85 into Lysosomes and with the Submembrane Displacement of TLR9","year":2017,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Galectins and Cancer Biology","field":"Immunology and Microbiology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; Maple Leaf Medical Clinic; University of Toronto","funders":"Canadian Institutes of Health Research; National Institutes of Health","keywords":"Buckypaper; TLR9; Plasmacytoid dendritic cell; Microvesicles; Human immunodeficiency virus (HIV); IRF7; Virology; Immunology; Cell biology; Medicine; Biology; Dendritic cell; Innate immune system; Immune system; Nanotechnology; Materials science; Genetics; microRNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002081187,0.0002255152,0.0001831377,0.0005795202,0.0002338763,0.0003559451,0.0001462007,0.0003924103,0.001846236],"category_scores_gemma":[0.0001646534,0.0001282576,0.0002158625,0.0003330806,0.0001905643,0.0001661573,0.00023671,0.0005350907,0.0002956145],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002101767,"about_ca_system_score_gemma":0.0001087525,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000257731,"about_ca_topic_score_gemma":0.0001908768,"domain_scores_codex":[0.9998603,0.00002020604,0.00001406132,0.00002777255,0.00003661683,0.00004100038],"domain_scores_gemma":[0.9999124,0.0000114349,0.0000317205,0.000008892321,0.00001352834,0.00002211063],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004324352,0.00003066707,0.01384106,0.00008379902,0.00002333375,0.0003112416,0.00007026185,0.00004388751,0.9811873,0.00009056437,0.00009279608,0.003792782],"study_design_scores_gemma":[0.00003226435,0.0005587763,0.2832386,0.00004449823,0.00008892592,0.004828541,0.0003203578,0.001977182,0.7056108,0.0003953683,0.002886245,0.00001836235],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995268,0.001237089,0.002363517,0.00004894058,0.0000131807,0.00003476718,0.0004186086,0.00004249818,0.0005733273],"genre_scores_gemma":[0.9975568,0.0003822257,0.001140014,0.00003142506,0.000009461322,0.0000305086,0.0003067614,0.000005343272,0.0005374236],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001846236,"threshold_uncertainty_score":0.006176233,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01040374634824577,"score_gpt":0.2225490440680903,"score_spread":0.2121452977198445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}