{"id":"W2603288306","doi":"10.4049/jimmunol.1601298","title":"Tim-3 is a Marker of Plasmacytoid Dendritic Cell Dysfunction during HIV Infection and Is Associated with the Recruitment of IRF7 and p85 into Lysosomes and with the Submembrane Displacement of TLR9","year":2017,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Galectins and Cancer Biology","field":"Immunology and Microbiology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; Maple Leaf Medical Clinic; University of Toronto","funders":"Canadian Institutes of Health Research; National Institutes of Health","keywords":"Buckypaper; TLR9; Plasmacytoid dendritic cell; Microvesicles; Human immunodeficiency virus (HIV); IRF7; Virology; Immunology; Cell biology; Medicine; Biology; Dendritic cell; Innate immune system; Immune system; Nanotechnology; Materials science; Genetics; microRNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005993508,0.0001369705,0.0003750287,0.00007095142,0.0003513129,0.000008900992,0.000167383,0.0001254092,0.00004696897],"category_scores_gemma":[0.00004293898,0.00006088438,0.00003798638,0.0000512506,0.001236975,0.00006947766,0.0001135328,0.0003011092,5.141063e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003372179,"about_ca_system_score_gemma":0.00006125907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002866903,"about_ca_topic_score_gemma":0.0002834213,"domain_scores_codex":[0.9990187,0.0003578641,0.0003036969,0.0001073077,0.00004674357,0.0001656692],"domain_scores_gemma":[0.9982916,0.0002534958,0.001040871,0.0002471642,0.0001553398,0.00001157763],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.006088835,0.000141419,0.07159878,0.00009491887,0.002028257,0.000002359307,0.005168435,0.00000613174,0.9127193,0.00007157602,0.0002461967,0.001833752],"study_design_scores_gemma":[0.005280015,0.003124782,0.6565814,0.0001687509,0.0005871211,0.0008514069,0.001861674,0.000004578477,0.3306125,0.00007911665,0.000742255,0.0001063467],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910512,0.006276152,0.00002290186,0.00217861,0.0001173749,0.0002361978,0.000008951147,0.000002191073,0.0001064381],"genre_scores_gemma":[0.9952482,0.004226391,0.000005990041,0.00005172605,0.000009479544,0.000007706508,0.00000157017,0.000008238031,0.000440706],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5849826,"threshold_uncertainty_score":0.4557688,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01040374634824577,"score_gpt":0.2225490440680903,"score_spread":0.2121452977198445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}