{"id":"W2603317135","doi":"10.1021/acs.biochem.6b00681","title":"Hyperinsulinism-Causing Mutations Cause Multiple Molecular Defects in SUR1 NBD1","year":2017,"lang":"en","type":"article","venue":"Biochemistry","topic":"Hyperglycemia and glycemic control in critically ill and hospitalized patients","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Ontario Ministry of Economic Development and Innovation; Canadian Institutes of Health Research; Rare Disease Foundation","keywords":"Sulfonylurea receptor; Kir6.2; Congenital hyperinsulinism; Cyclic nucleotide-binding domain; Hyperinsulinism; Mutation; Chemistry; Protein subunit; Biochemistry; Biology; Nucleotide; Insulin; Endocrinology; Gene; Insulin resistance","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001134002,0.0007032536,0.0003223876,0.0003646613,0.0002715173,0.000224602,0.0002959992,0.0005227154,0.001582118],"category_scores_gemma":[0.0003102438,0.0001544959,0.0004213557,0.0002587691,0.0004936589,0.0001668205,0.0003719362,0.0005270221,0.0004134773],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003823189,"about_ca_system_score_gemma":0.0001686219,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001006469,"about_ca_topic_score_gemma":0.001048506,"domain_scores_codex":[0.9997159,0.00002643635,0.00004656311,0.00009117615,0.00009182765,0.00002801467],"domain_scores_gemma":[0.9997619,0.00004947306,0.00008364482,0.00001308763,0.0000181203,0.00007381531],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002058189,0.0000468274,0.003870154,0.00006043341,0.00003885906,0.01047843,0.0001301789,0.000342778,0.9803945,0.0001907307,0.0001521555,0.004089229],"study_design_scores_gemma":[0.0001729243,0.0006975759,0.1278072,0.00006215018,0.0002061633,0.1010671,0.0003225476,0.005081913,0.7549896,0.0004119265,0.009092839,0.00008823168],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964856,0.0005714015,0.001532332,0.0001065576,0.00005659999,0.0000154367,0.000376089,0.00006111339,0.000794926],"genre_scores_gemma":[0.9976438,0.0003216412,0.001187997,0.00007289929,0.00001927908,0.000006955432,0.0003143351,0.00002114324,0.000411934],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001582118,"threshold_uncertainty_score":0.005292714,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0243230680218124,"score_gpt":0.3102320862805925,"score_spread":0.2859090182587801,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}