{"id":"W2603648359","doi":"10.1245/s10434-017-5830-6","title":"TOPGEAR: A Randomized, Phase III Trial of Perioperative ECF Chemotherapy with or Without Preoperative Chemoradiation for Resectable Gastric Cancer: Interim Results from an International, Intergroup Trial of the AGITG, TROG, EORTC and CCTG","year":2017,"lang":"en","type":"article","venue":"Annals of Surgical Oncology","topic":"Gastric Cancer Management and Outcomes","field":"Medicine","cited_by":243,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; Toronto General Hospital; Mount Sinai Hospital","funders":"Health Research Council of New Zealand; National Health and Medical Research Council; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Cancer Australia","keywords":"Medicine; Epirubicin; Perioperative; Interim analysis; Surgical oncology; Surgery; Preoperative care; Chemotherapy; Chemoradiotherapy; Randomized controlled trial; Cancer; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009526295,0.0001852773,0.001429465,0.0001070977,0.00008889412,0.00003316866,0.0002942536,0.0001121143,0.0001553972],"category_scores_gemma":[0.0004625075,0.0001013057,0.0002252051,0.00009430612,0.0005923439,0.0002589447,0.00009032691,0.0001430126,1.246327e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005507866,"about_ca_system_score_gemma":0.0003167965,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00137257,"about_ca_topic_score_gemma":0.0004901908,"domain_scores_codex":[0.9981624,0.0002115296,0.0008340664,0.0003323754,0.0002786296,0.0001810042],"domain_scores_gemma":[0.9974363,0.000491437,0.001138027,0.0003907133,0.000462453,0.00008110541],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9741983,0.001105379,0.0006284691,0.00002765982,0.0007860684,0.000007903528,0.002043003,0.000004760802,0.0002584262,0.0001493789,0.0004747851,0.02031588],"study_design_scores_gemma":[0.962054,0.01664142,0.0005089158,0.0001545522,0.0002753977,0.000006655928,0.0004539972,0.0009319141,0.004887464,0.00003185264,0.01395641,0.00009741979],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9800794,0.0000750564,0.0001124392,0.0128902,0.0005621765,0.003608938,0.0001625725,0.00000797875,0.002501238],"genre_scores_gemma":[0.9935756,0.00305308,0.0004136389,0.0002118779,0.0005031904,0.0003207072,0.00005345734,0.00001534336,0.001853125],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02021846,"threshold_uncertainty_score":0.4131128,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08781135775301484,"score_gpt":0.4378336195095799,"score_spread":0.3500222617565651,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}