{"id":"W2603648359","doi":"10.1245/s10434-017-5830-6","title":"TOPGEAR: A Randomized, Phase III Trial of Perioperative ECF Chemotherapy with or Without Preoperative Chemoradiation for Resectable Gastric Cancer: Interim Results from an International, Intergroup Trial of the AGITG, TROG, EORTC and CCTG","year":2017,"lang":"en","type":"article","venue":"Annals of Surgical Oncology","topic":"Gastric Cancer Management and Outcomes","field":"Medicine","cited_by":243,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; Toronto General Hospital; Mount Sinai Hospital","funders":"Health Research Council of New Zealand; National Health and Medical Research Council; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Cancer Australia","keywords":"Medicine; Epirubicin; Perioperative; Interim analysis; Surgical oncology; Surgery; Preoperative care; Chemotherapy; Chemoradiotherapy; Randomized controlled trial; Cancer; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002052427,0.002737502,0.003647343,0.0005436217,0.0004499189,0.001758557,0.001399628,0.001591868,0.007970444],"category_scores_gemma":[0.001786358,0.0007075516,0.003147064,0.0005993153,0.001972868,0.001969147,0.0007301499,0.005815425,0.001641661],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009883473,"about_ca_system_score_gemma":0.001481799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001337671,"about_ca_topic_score_gemma":0.003902268,"domain_scores_codex":[0.9991724,0.0004461725,0.00003116288,0.0001478846,0.00004752805,0.0001547615],"domain_scores_gemma":[0.9991807,0.0002147896,0.0001615615,0.0001026757,0.00003456631,0.0003057807],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9744331,0.005448913,0.0006347118,0.0004460575,0.001656117,0.00002863778,0.00004586371,0.0006604791,0.001577793,0.0002352302,0.001938251,0.01289475],"study_design_scores_gemma":[0.9669476,0.03026175,0.0008627736,0.00001901365,0.0006994341,0.00002360461,0.00002583781,0.0002302762,0.0002288929,0.0001669292,0.0005215061,0.00001229104],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9799342,0.005695695,0.001279511,0.002161558,0.001323194,0.002665089,0.003022254,0.0003098753,0.003608598],"genre_scores_gemma":[0.9689868,0.005008365,0.004041059,0.003711002,0.001021255,0.005818435,0.005476017,0.0001456301,0.005791483],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007970444,"threshold_uncertainty_score":0.02666384,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08781135775301484,"score_gpt":0.4378336195095799,"score_spread":0.3500222617565651,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}