{"id":"W2603709537","doi":"10.1158/1538-7445.transcontrol16-a31","title":"Abstract A31: eIF4F links translation to energy stress response in cancer","year":2017,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; British Columbia Institute of Technology; McGill University","funders":"","keywords":"Cancer; Cancer cell; Biology; mTORC1; Kinase; Cancer research; Integrated stress response; PI3K/AKT/mTOR pathway; Carcinogenesis; Translational efficiency; Translation (biology); Cell biology; Signal transduction; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000195444,0.000323537,0.0002945322,0.0002734064,0.00028455,0.0003239324,0.0001837641,0.0004119494,0.004037872],"category_scores_gemma":[0.0001352503,0.0001086907,0.0003167716,0.0002356619,0.000164296,0.0001775009,0.0002756662,0.0005095789,0.0008064743],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004160425,"about_ca_system_score_gemma":0.000297521,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004349675,"about_ca_topic_score_gemma":0.0003994231,"domain_scores_codex":[0.9998783,0.00001728329,0.00001402808,0.00002817989,0.00003255004,0.0000296501],"domain_scores_gemma":[0.999907,0.00001048893,0.00003156938,0.000008336765,0.00001854198,0.00002399863],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007250455,0.00006858235,0.001096098,0.0002727421,0.00002514055,0.0002147777,0.00001113624,0.0002070927,0.9871765,0.0003058872,0.0008465799,0.009050342],"study_design_scores_gemma":[0.00008193182,0.0008011504,0.02746036,0.00003911536,0.00004876153,0.0008574552,0.00005402445,0.001567765,0.940836,0.0005015219,0.02773215,0.00001972225],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9492463,0.02691048,0.008052253,0.001784785,0.0009037781,0.0001432887,0.003759854,0.000687138,0.008512197],"genre_scores_gemma":[0.9879695,0.003346255,0.002192561,0.0002582376,0.00005658452,0.00004430963,0.001603981,0.00002861576,0.004499966],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004037872,"threshold_uncertainty_score":0.01350808,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08489605755528071,"score_gpt":0.4272989880783974,"score_spread":0.3424029305231167,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}