{"id":"W2603753629","doi":"10.1016/j.neuron.2017.02.046","title":"Regulatory Role of RNA Chaperone TDP-43 for RNA Misfolding and Repeat-Associated Translation in SCA31","year":2017,"lang":"en","type":"article","venue":"Neuron","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":143,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Core Research for Evolutional Science and Technology; National Institute of Neurological Disorders and Stroke; Research Committee for Ataxic Disease; Japan Science and Technology Agency; Howard Hughes Medical Institute; Ministry of Education, Culture, Sports, Science and Technology; Japan Society for the Promotion of Science; Ministry of Health, Labour and Welfare; Japan Agency for Medical Research and Development","keywords":"RNA; Translation (biology); Biology; Spinocerebellar ataxia; RNA-binding protein; Neurodegeneration; Cell biology; Trinucleotide repeat expansion; Ataxia; Genetics; Messenger RNA; Gene; Neuroscience; Disease; Medicine; Pathology; Allele","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004267937,0.0003579536,0.0005040293,0.0002674458,0.0008424216,0.0007317091,0.0003501452,0.0006517883,0.00290107],"category_scores_gemma":[0.0004722972,0.0002360631,0.0003930581,0.0000950175,0.0005042867,0.0005001554,0.0004874917,0.000663977,0.00105969],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007644938,"about_ca_system_score_gemma":0.0005616209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009228825,"about_ca_topic_score_gemma":0.001495344,"domain_scores_codex":[0.9997358,0.0000472795,0.00002428327,0.00008647799,0.00004856392,0.0000576427],"domain_scores_gemma":[0.9996917,0.00005962501,0.00006728601,0.00003529903,0.00005122654,0.00009478321],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004569286,0.00007174199,0.0009434666,0.0000453207,0.000008994922,0.0009457412,0.00008012791,0.0003791955,0.9927579,0.00116344,0.0005407399,0.002606416],"study_design_scores_gemma":[0.0000839625,0.0004492901,0.0367542,0.00003921426,0.00003894046,0.001337912,0.0003348736,0.0203511,0.9335216,0.002042039,0.004998639,0.00004830517],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913867,0.001724765,0.003890591,0.0003696411,0.0001673858,0.00002871843,0.0001667432,0.000323776,0.001941817],"genre_scores_gemma":[0.9971377,0.0001480249,0.001462599,0.00006242081,0.00001496258,0.00001399974,0.0001140224,0.00004908544,0.0009971517],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00290107,"threshold_uncertainty_score":0.009705067,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04303246418932737,"score_gpt":0.2815036659750706,"score_spread":0.2384712017857433,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}