{"id":"W2603753629","doi":"10.1016/j.neuron.2017.02.046","title":"Regulatory Role of RNA Chaperone TDP-43 for RNA Misfolding and Repeat-Associated Translation in SCA31","year":2017,"lang":"en","type":"article","venue":"Neuron","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":143,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Core Research for Evolutional Science and Technology; National Institute of Neurological Disorders and Stroke; Research Committee for Ataxic Disease; Japan Science and Technology Agency; Howard Hughes Medical Institute; Ministry of Education, Culture, Sports, Science and Technology; Japan Society for the Promotion of Science; Ministry of Health, Labour and Welfare; Japan Agency for Medical Research and Development","keywords":"RNA; Translation (biology); Biology; Spinocerebellar ataxia; RNA-binding protein; Neurodegeneration; Cell biology; Trinucleotide repeat expansion; Ataxia; Genetics; Messenger RNA; Gene; Neuroscience; Disease; Medicine; Pathology; Allele","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001314314,0.0001311689,0.0001832683,0.00008326301,0.000215257,0.00005221647,0.0002138631,0.00005143514,0.00000704987],"category_scores_gemma":[0.001071505,0.0001409841,0.00005329226,0.00005979395,0.0001343861,0.0001806668,0.00004151919,0.000075891,0.000001147313],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001653078,"about_ca_system_score_gemma":0.00002823653,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002103944,"about_ca_topic_score_gemma":0.00003230838,"domain_scores_codex":[0.9987812,0.000115477,0.0002330914,0.0004491475,0.0002014997,0.0002195899],"domain_scores_gemma":[0.9991097,0.00018656,0.000220493,0.0003845647,0.00003268174,0.0000659564],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005782398,0.00006630551,0.004242845,0.00001885788,0.000001329092,0.000002543294,0.0001694279,0.00007400133,0.9835851,0.0001665577,0.00001408684,0.01160117],"study_design_scores_gemma":[0.0007498875,0.0001190624,0.2365635,0.0000234398,0.00001085818,8.449604e-7,0.00001174183,0.001908317,0.7600952,0.000359289,0.00006803321,0.00008983686],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983419,0.0001438047,0.00001210154,0.0002491738,0.0001417444,0.0004005979,0.00003360601,0.00002484654,0.00065225],"genre_scores_gemma":[0.9995976,0.00005781008,0.00006287419,0.0001221803,0.0000328335,0.00002531418,0.000002138229,0.00002620547,0.00007304554],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2323207,"threshold_uncertainty_score":0.5749165,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04303246418932737,"score_gpt":0.2815036659750706,"score_spread":0.2384712017857433,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}