{"id":"W2603821422","doi":"10.1007/s40268-017-0180-1","title":"Revisiting CDK Inhibitors for Treatment of Glioblastoma Multiforme","year":2017,"lang":"en","type":"review","venue":"Drugs in R&D","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Windsor","funders":"Canadian Cancer Society Research Institute","keywords":"Cyclin-dependent kinase; Glioma; Glioblastoma; Repurposing; Disease; Medicine; Population; Biology; Bioinformatics; Cancer research; Cancer; Cell cycle; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001827059,0.0004387038,0.002748536,0.0003741226,0.00006965231,0.000020639,0.0001187959,0.0002596256,0.00001884277],"category_scores_gemma":[0.0001491532,0.0002963517,0.001031242,0.0001241216,0.00005478796,0.00003924813,0.00003546013,0.0000696704,0.00003173265],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005001179,"about_ca_system_score_gemma":0.0002047023,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007710794,"about_ca_topic_score_gemma":0.00001294215,"domain_scores_codex":[0.9981998,0.00003730076,0.0008370584,0.000419598,0.0001867247,0.0003195334],"domain_scores_gemma":[0.9980963,0.0003481278,0.0007007832,0.0006787439,0.00006995606,0.0001060388],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003075294,0.0004825912,0.0002513142,0.01341174,0.0002682749,0.00006360699,0.0001580109,1.94492e-7,5.21967e-7,0.00004517821,0.0001216646,0.9851661],"study_design_scores_gemma":[0.002602809,0.0006730176,0.00005128638,0.04200732,0.0015839,0.00003992613,0.00004007426,0.000009804572,0.0001254589,0.000008647438,0.9526526,0.0002051335],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00120843,0.9947694,7.87478e-7,0.00005992435,0.0002395378,0.00280624,0.0001404555,0.00002184257,0.000753411],"genre_scores_gemma":[0.00121526,0.9961106,0.0006043549,0.000005699495,0.0004634271,0.001124226,0.0001793979,0.00006732991,0.0002296848],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.984961,"threshold_uncertainty_score":0.9999489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08373018955416103,"score_gpt":0.4042266653883339,"score_spread":0.3204964758341728,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}