{"id":"W2603952611","doi":"10.1111/apt.14052","title":"Reversal of hepatorenal syndrome type 1 with terlipressin plus albumin vs. placebo plus albumin in a pooled analysis of the <scp>OT</scp>‐0401 and <scp>REVERSE</scp> randomised clinical studies","year":2017,"lang":"en","type":"article","venue":"Alimentary Pharmacology & Therapeutics","topic":"Liver Disease and Transplantation","field":"Medicine","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Genentech; Ikaria; Intercept Pharmaceuticals; AbbVie; Gilead Sciences","keywords":"Terlipressin; Hepatorenal syndrome; Medicine; Placebo; Renal function; Albumin; Internal medicine; Gastroenterology; Creatinine; Urology; Anesthesia; Surgery; Cirrhosis; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006808689,0.0003168258,0.001216701,0.0002447286,0.0001723778,0.00001514542,0.0002925167,0.0001690106,0.00002838135],"category_scores_gemma":[0.000007329775,0.0002212482,0.0002633414,0.0003185699,0.001045716,0.000174083,0.0001169264,0.0003694137,0.000002847743],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001044155,"about_ca_system_score_gemma":0.0003108318,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002564799,"about_ca_topic_score_gemma":0.0001627442,"domain_scores_codex":[0.9975584,0.0005399659,0.0007424911,0.0004364736,0.0003709983,0.0003516753],"domain_scores_gemma":[0.9971389,0.00144795,0.0006536616,0.0004610037,0.0001534806,0.0001449854],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01102031,0.00081601,0.7882596,0.000329533,0.1670829,0.0005528412,0.006845122,0.0001688683,0.0243197,0.000007544177,0.000475096,0.0001224452],"study_design_scores_gemma":[0.08405235,0.00119934,0.6220161,0.0003108752,0.2568173,0.00009352241,0.002264758,0.002480456,0.03045781,0.00002175112,0.0001847068,0.0001009964],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953696,0.002374802,0.000008339794,0.0004822451,0.0004019566,0.001160469,0.0001011021,0.0000167064,0.00008473984],"genre_scores_gemma":[0.9935979,0.003012361,0.0001251116,0.002835908,0.00006604705,0.00004484504,0.00007276962,0.00002855051,0.000216544],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1662435,"threshold_uncertainty_score":0.9022241,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05370620661905318,"score_gpt":0.3711902203506113,"score_spread":0.3174840137315581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}