{"id":"W2603977557","doi":"10.1200/jco.2017.35.4_suppl.593","title":"Cancer stemness inhibition and chemosensitization: Phase 1b/II study of cancer stemness inhibitor napabucasin (BBI-608) with FOLFIRI +/- bevacizumab (Bev) administered to colorectal cancer (CRC) patients (pts).","year":2017,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"Medicine; Irinotecan; Colorectal cancer; Bevacizumab; Internal medicine; Cancer; FOLFIRI; Tolerability; Oncology; Phases of clinical research; Combination therapy; Pharmacology; Gastroenterology; Adverse effect; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001018127,0.001380281,0.00166819,0.0005426249,0.0003551065,0.0006995075,0.0007137412,0.00111544,0.002687663],"category_scores_gemma":[0.0004533263,0.0006032162,0.001020928,0.0004502592,0.001046493,0.0006186403,0.0003220645,0.00218205,0.0005357364],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009020508,"about_ca_system_score_gemma":0.001605447,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001362255,"about_ca_topic_score_gemma":0.002839897,"domain_scores_codex":[0.9996573,0.0001330876,0.0000169689,0.00006219467,0.00003769492,0.00009288178],"domain_scores_gemma":[0.9996501,0.00004148077,0.00006169704,0.00003295539,0.00002148641,0.0001922014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5239297,0.1873382,0.005910351,0.0009430912,0.0009345775,0.0003380625,0.0004190339,0.002917526,0.1832445,0.0003970801,0.002680942,0.09094699],"study_design_scores_gemma":[0.2084109,0.7583246,0.009769229,0.00002901788,0.0003975841,0.0003101161,0.00005758733,0.001077326,0.01929778,0.0001203496,0.002182019,0.00002348629],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954088,0.001076305,0.0003748248,0.0001700789,0.00004608268,0.001804605,0.0003720367,0.00004866089,0.0006985694],"genre_scores_gemma":[0.9905176,0.001459015,0.0015783,0.00037645,0.00009690829,0.002285334,0.001273268,0.00002194757,0.002391077],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002687663,"threshold_uncertainty_score":0.008991122,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2832378062763108,"score_gpt":0.5737039434525277,"score_spread":0.2904661371762169,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}