{"id":"W2603977557","doi":"10.1200/jco.2017.35.4_suppl.593","title":"Cancer stemness inhibition and chemosensitization: Phase 1b/II study of cancer stemness inhibitor napabucasin (BBI-608) with FOLFIRI +/- bevacizumab (Bev) administered to colorectal cancer (CRC) patients (pts).","year":2017,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"Medicine; Irinotecan; Colorectal cancer; Bevacizumab; Internal medicine; Cancer; FOLFIRI; Tolerability; Oncology; Phases of clinical research; Combination therapy; Pharmacology; Gastroenterology; Adverse effect; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001669843,0.0003769046,0.001728124,0.0001760911,0.0007883009,0.00005970369,0.0004034056,0.0005807364,0.0003465163],"category_scores_gemma":[0.0005251337,0.0002919934,0.0002032728,0.0001900584,0.0006352836,0.0004365528,0.0003227193,0.001274353,0.00000309651],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000310564,"about_ca_system_score_gemma":0.00122362,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003544513,"about_ca_topic_score_gemma":0.00480737,"domain_scores_codex":[0.9954709,0.000937899,0.00214366,0.0005090934,0.0004995625,0.0004388984],"domain_scores_gemma":[0.9927837,0.0006962186,0.00399335,0.0002606186,0.001708382,0.0005577276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03769511,0.02621165,0.7506431,0.0001737451,0.001799253,0.0004666815,0.002340514,0.0001075837,0.004837951,0.00002194132,0.004205748,0.1714967],"study_design_scores_gemma":[0.1177379,0.0507705,0.7634136,0.0006769111,0.002364061,0.00009299984,0.001760738,0.0003318222,0.02056927,0.00004155228,0.04139785,0.0008428144],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894952,0.0003739648,0.00001743866,0.003299682,0.005293605,0.001041037,0.0002152726,0.00001310025,0.0002507216],"genre_scores_gemma":[0.9959723,0.0005902058,0.00007821853,0.001486606,0.001548347,0.00009588093,0.000007930103,0.00004089583,0.0001795559],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1706539,"threshold_uncertainty_score":0.9999532,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2832378062763108,"score_gpt":0.5737039434525277,"score_spread":0.2904661371762169,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}