{"id":"W2604011841","doi":"","title":"Repeated synchronous photoactivation of T4K rhodopsin induces outer segment shedding and retinal degeneration in a Xenopus laevis model of retinitis pigmentosa","year":2016,"lang":"en","type":"article","venue":"","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Retinitis pigmentosa; Xenopus; Rhodopsin; Retinal degeneration; Gene therapy of the human retina; Retinal; Degeneration (medical); Ophthalmology; Biology; Cell biology; Anatomy; Medicine; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003284029,0.0005987906,0.0004641701,0.0006450447,0.0003230097,0.0004412914,0.0004116265,0.0008664593,0.002444366],"category_scores_gemma":[0.0001912543,0.0003038554,0.0007909664,0.0002542861,0.0006156229,0.0004056983,0.0002780071,0.001484892,0.0004045364],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007198608,"about_ca_system_score_gemma":0.0004122633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002707276,"about_ca_topic_score_gemma":0.00344588,"domain_scores_codex":[0.9996111,0.00006775416,0.00004642163,0.00007954163,0.00006428455,0.0001309164],"domain_scores_gemma":[0.9995401,0.00006870615,0.0001384353,0.0000584528,0.00002672876,0.0001676761],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004048137,0.0001022987,0.00007246422,0.00002186524,0.000008919794,0.0001109728,0.00002256732,0.0000544761,0.9988102,0.0001003258,0.00004158691,0.0002495588],"study_design_scores_gemma":[0.00006908159,0.0006336733,0.001972929,0.000006603865,0.00002194095,0.0001881274,0.00007137522,0.0007994434,0.9958126,0.00004412506,0.0003716414,0.000008419834],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975833,0.000412075,0.0007684315,0.0001349797,0.00007605558,0.00003470779,0.0002320574,0.00009485266,0.0006634631],"genre_scores_gemma":[0.9933155,0.0003394894,0.0008781025,0.00007203843,0.00002014977,0.00006246827,0.0002453525,0.00004959872,0.005017254],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002707276,"threshold_uncertainty_score":0.008177161,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01338417423923679,"score_gpt":0.2353807565035323,"score_spread":0.2219965822642955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}