{"id":"W2604115697","doi":"10.1021/acsami.7b02281","title":"Polyphosphoester-Camptothecin Prodrug with Reduction-Response Prepared via Michael Addition Polymerization and Click Reaction","year":2017,"lang":"en","type":"article","venue":"ACS Applied Materials & Interfaces","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Soochow University; Priority Academic Program Development of Jiangsu Higher Education Institutions; University of Waterloo; National Natural Science Foundation of China","keywords":"Prodrug; Camptothecin; Materials science; Click chemistry; Michael reaction; Polymerization; Reduction (mathematics); Combinatorial chemistry; Polymer chemistry; Organic chemistry; Polymer; Catalysis; Chemistry; Pharmacology; Medicine; Composite material","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001544418,0.0005088234,0.000196511,0.0001458975,0.00008421001,0.0001189949,0.0001924246,0.0003036469,0.0008251628],"category_scores_gemma":[0.0001281427,0.0001916198,0.0002478184,0.0001485433,0.0001439455,0.0002933289,0.0001892134,0.0004441417,0.0003324486],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002474708,"about_ca_system_score_gemma":0.0001610757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002403771,"about_ca_topic_score_gemma":0.000291482,"domain_scores_codex":[0.9998626,0.0000156416,0.00001313141,0.00004096303,0.00004332124,0.00002441793],"domain_scores_gemma":[0.9999479,0.00000845193,0.00002185681,0.000005215323,0.000007293867,0.000009327949],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003821002,0.00001446547,0.00006300542,0.00004996636,0.000005509507,0.00008441523,0.000009122802,0.0001197872,0.99701,0.0002207748,0.00004042052,0.002344385],"study_design_scores_gemma":[0.000008571854,0.0001474767,0.0003726009,0.000001183462,0.000006734102,0.0002071345,0.000001992456,0.0004182023,0.9974171,0.00002291717,0.001392144,0.000003909397],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9411592,0.003609595,0.04861905,0.0001907426,0.00007270577,0.0002929283,0.000364447,0.0003815555,0.005309702],"genre_scores_gemma":[0.9736839,0.001255386,0.0198433,0.00008799972,0.00002014959,0.0001494214,0.0002823104,0.00002129139,0.004656289],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008251628,"threshold_uncertainty_score":0.00276047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006197740082170043,"score_gpt":0.2476298198491764,"score_spread":0.2414320797670064,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}