{"id":"W2604170775","doi":"10.1158/1557-3125.dnarepair16-ia08","title":"Abstract IA08: Synthetic viability due to BRCA2 and PARP1 loss","year":2017,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Synthetic lethality; PARP1; Olaparib; Cancer research; Biology; Poly ADP ribose polymerase; PARP inhibitor; Cancer cell; Mutation; Cancer; Programmed cell death; Apoptosis; DNA repair; Genetics; Polymerase; DNA; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001920064,0.0004085158,0.0003513312,0.0004411543,0.0002397387,0.0003834266,0.0004104375,0.0006007986,0.005364494],"category_scores_gemma":[0.0003495669,0.0001339327,0.0002589728,0.0002663773,0.0002658724,0.0001657147,0.0004301996,0.001160665,0.001823302],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002030776,"about_ca_system_score_gemma":0.0001875814,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004722632,"about_ca_topic_score_gemma":0.0002092539,"domain_scores_codex":[0.9997497,0.00004737173,0.00003264359,0.00004521799,0.00007774259,0.00004736762],"domain_scores_gemma":[0.9993101,0.0001560618,0.0001619754,0.0001187718,0.00006481132,0.0001882296],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001964704,0.00008867618,0.0007714437,0.00003684441,0.00001038171,0.0005419041,0.00003012305,0.0001185881,0.9942009,0.0002772766,0.0005765156,0.003150739],"study_design_scores_gemma":[0.00002745946,0.0009129632,0.008727501,0.00001632922,0.00002612011,0.004252443,0.00005991877,0.001165613,0.9760846,0.000210977,0.008504634,0.00001151627],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98264,0.002112532,0.00370545,0.0003481115,0.00009507754,0.00004174905,0.002124255,0.0004977343,0.008434984],"genre_scores_gemma":[0.987641,0.0004697409,0.001612927,0.0001428235,0.00001689949,0.00005703252,0.003051145,0.0001383924,0.006869864],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005364494,"threshold_uncertainty_score":0.01794606,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08981638857740393,"score_gpt":0.461485435438294,"score_spread":0.37166904686089,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}