{"id":"W2604205643","doi":"10.1158/1078-0432.ccr-16-3230","title":"Vulvar Squamous Cell Carcinoma (VSCC) as Two Diseases: HPV Status Identifies Distinct Mutational Profiles Including Oncogenic Fibroblast Growth Factor Receptor 3","year":2017,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cervical Cancer and HPV Research","field":"Medicine","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Ottawa Hospital; Ontario Institute for Cancer Research","funders":"","keywords":"HRAS; CDKN2A; PTEN; Oncology; Cancer research; Vulvar Carcinoma; Vulva; Fibroblast growth factor receptor 3; Papillomaviridae; Internal medicine; Medicine; Cancer; Biology; Carcinoma; Pathology; KRAS; Cervical cancer; Genetics; PI3K/AKT/mTOR pathway; Receptor; Fibroblast growth factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","sts","research_integrity","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.001986222,0.0004053673,0.0009076914,0.0003330529,0.001889111,0.0006481594,0.001186538,0.0002927537,0.03022912],"category_scores_gemma":[0.01139779,0.0003404664,0.0005290877,0.0004459695,0.002173727,0.0004482702,0.001528178,0.002343362,0.001231954],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001045474,"about_ca_system_score_gemma":0.00429645,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008542823,"about_ca_topic_score_gemma":0.001178463,"domain_scores_codex":[0.9917754,0.000766158,0.001132663,0.001404858,0.003144874,0.001776051],"domain_scores_gemma":[0.9912683,0.002668659,0.0003042997,0.001418263,0.002397203,0.001943235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007223716,0.001368166,0.917407,0.00208898,0.0001629615,0.0004522082,0.0005185729,0.000003595908,0.002584737,0.00036713,0.02407254,0.04375042],"study_design_scores_gemma":[0.007127978,0.00168546,0.976932,0.0001081847,0.0000871827,0.000008279414,0.0003438517,0.0001887798,0.006423068,0.00130874,0.00537041,0.0004160489],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9727098,0.002133816,0.00001790998,0.002881235,0.0006967964,0.001657106,0.001122951,0.0000964682,0.01868393],"genre_scores_gemma":[0.9886,0.0005580417,0.000106759,0.0001880697,0.002785964,0.0005759966,0.0002610763,0.0001126905,0.006811446],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05952504,"threshold_uncertainty_score":0.9999583,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2127881975698915,"score_gpt":0.5204065018682588,"score_spread":0.3076183042983672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}