{"id":"W2604205643","doi":"10.1158/1078-0432.ccr-16-3230","title":"Vulvar Squamous Cell Carcinoma (VSCC) as Two Diseases: HPV Status Identifies Distinct Mutational Profiles Including Oncogenic Fibroblast Growth Factor Receptor 3","year":2017,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cervical Cancer and HPV Research","field":"Medicine","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Ottawa Hospital; Ontario Institute for Cancer Research","funders":"","keywords":"HRAS; CDKN2A; PTEN; Oncology; Cancer research; Vulvar Carcinoma; Vulva; Fibroblast growth factor receptor 3; Papillomaviridae; Internal medicine; Medicine; Cancer; Biology; Carcinoma; Pathology; KRAS; Cervical cancer; Genetics; PI3K/AKT/mTOR pathway; Receptor; Fibroblast growth factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003578294,0.0002121174,0.0002460643,0.0008493331,0.0003743221,0.0005504655,0.0001965972,0.0002463862,0.001575877],"category_scores_gemma":[0.0006809115,0.0001395401,0.0002210403,0.0008881861,0.0003659715,0.000293951,0.0003395605,0.0001751714,0.0001545401],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003576441,"about_ca_system_score_gemma":0.0004476627,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002035196,"about_ca_topic_score_gemma":0.004472147,"domain_scores_codex":[0.9997084,0.00004857273,0.00003985543,0.00007430164,0.00007483271,0.00005409298],"domain_scores_gemma":[0.9996285,0.00007785009,0.0001430226,0.00003122057,0.00005137413,0.00006797696],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001317826,0.000009247304,0.9955871,0.0000171629,0.0000216987,0.0003901536,0.0000371229,0.00003244873,0.001417981,0.00002727123,0.00004344654,0.002284521],"study_design_scores_gemma":[0.00000650938,0.0001068886,0.9929195,0.00001672108,0.0000428596,0.005356268,0.0002334181,0.0001430753,0.0007822938,0.00005595823,0.0003325193,0.000004067926],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986615,0.0006199014,0.000097361,0.00001305795,0.000003430903,0.000009817801,0.0001856222,0.000003092521,0.0004061849],"genre_scores_gemma":[0.9996594,0.0001084093,0.00005522248,0.000005983826,0.00000222575,0.000002307703,0.0001241873,6.065963e-7,0.00004164752],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002035196,"threshold_uncertainty_score":0.005271852,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2127881975698915,"score_gpt":0.5204065018682588,"score_spread":0.3076183042983672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}