{"id":"W2604241735","doi":"10.1158/1557-3125.dnarepair16-b38","title":"Abstract B38: Radiation enhances intracellular delivery of anti-MGMT oligomers to reduce protein expression in vitro and in a xenograft model","year":2017,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Temozolomide; Cancer research; In vivo; Methyltransferase; In vitro; DNA repair; Glioma; Cancer; Biology; Methylation; DNA; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006044183,0.0001350286,0.0001931809,0.000254507,0.0000927362,0.00006280454,0.0004033971,0.0001518789,0.000006489715],"category_scores_gemma":[0.0001281029,0.0001375225,0.0000452976,0.0001198312,0.000144563,0.0000220239,0.0002655655,0.0002259708,0.000002616253],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004917262,"about_ca_system_score_gemma":0.0002153694,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00108094,"about_ca_topic_score_gemma":0.0003160413,"domain_scores_codex":[0.9984696,0.00009367873,0.0002527803,0.0004655117,0.0003073986,0.0004110535],"domain_scores_gemma":[0.9991604,0.00000735726,0.00008848728,0.0004985711,0.0001409005,0.0001042687],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000567149,0.00006102293,0.0007429727,0.00005569445,0.00001221926,0.00002469428,0.0001416515,0.001447052,0.9882436,0.000002538792,0.00006511216,0.008636292],"study_design_scores_gemma":[0.0004836009,0.0001018157,0.005411121,0.0001987598,0.000001985636,7.175728e-7,0.0000814495,0.0009061427,0.9924664,0.00005313209,0.0001500132,0.0001448228],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960346,0.00267155,0.0002456542,0.0003223758,0.00002907365,0.0005104459,0.00001742162,0.000002533738,0.0001663126],"genre_scores_gemma":[0.9979594,0.001232789,0.0004265751,0.00003647687,0.00003221638,0.0001976866,0.00001668264,0.00001867253,0.00007954031],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00849147,"threshold_uncertainty_score":0.5608004,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03445662960900088,"score_gpt":0.3583844082506419,"score_spread":0.3239277786416411,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}