{"id":"W2604241735","doi":"10.1158/1557-3125.dnarepair16-b38","title":"Abstract B38: Radiation enhances intracellular delivery of anti-MGMT oligomers to reduce protein expression in vitro and in a xenograft model","year":2017,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Temozolomide; Cancer research; In vivo; Methyltransferase; In vitro; DNA repair; Glioma; Cancer; Biology; Methylation; DNA; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001104371,0.0004346604,0.0002228218,0.0001458196,0.00006842574,0.0001010425,0.0001611776,0.0002460357,0.001395808],"category_scores_gemma":[0.00004920468,0.0001060678,0.0002099632,0.00009885016,0.0001167587,0.0001219134,0.00007424823,0.0004030581,0.0002792937],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000157716,"about_ca_system_score_gemma":0.0001142865,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005298162,"about_ca_topic_score_gemma":0.0005479536,"domain_scores_codex":[0.9999247,0.00001146902,0.000006406914,0.00002107251,0.00002219696,0.00001414061],"domain_scores_gemma":[0.999956,0.00000759779,0.00001601686,0.000005520777,0.000006076383,0.000008805734],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003231288,0.00001812615,0.00001190657,0.00001602979,0.000001741726,0.00000492024,0.000003554951,0.00002806509,0.9995915,0.00001515428,0.00001345002,0.000263119],"study_design_scores_gemma":[0.000009251859,0.0005909707,0.0004673644,0.000002259904,0.00000716229,0.00003618928,0.000002983455,0.0002933117,0.9978289,0.000007062273,0.0007532243,0.000001387838],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924226,0.001334204,0.004625652,0.00006487767,0.00004376187,0.00005283705,0.0003262688,0.00012077,0.001009002],"genre_scores_gemma":[0.9872547,0.001027152,0.007118711,0.00003981351,0.00001302873,0.00008673791,0.0005611273,0.0000366021,0.003862048],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001395808,"threshold_uncertainty_score":0.004669487,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03445662960900088,"score_gpt":0.3583844082506419,"score_spread":0.3239277786416411,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}