{"id":"W2604244818","doi":"10.1158/1557-3125.dnarepair16-b19","title":"Abstract B19: The ATR inhibitor, AZD6738, synergizes with other DNA damage response inhibitors and genotoxic drugs in pancreatic ductal adenocarcinoma cell lines: Opportunities for new therapeutic combinations","year":2017,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Cancer research; DNA damage; PARP1; PARP inhibitor; CHEK1; Biology; Pancreatic cancer; DNA repair; Olaparib; Cell cycle checkpoint; Cancer; Cell cycle; DNA; Poly ADP ribose polymerase; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002759786,0.0007124314,0.0008834082,0.0007361896,0.0002271967,0.000406854,0.0004527355,0.0003745913,0.003527972],"category_scores_gemma":[0.0001429419,0.0002550062,0.0004477921,0.0006048863,0.0002005111,0.0002821917,0.0002603182,0.000853379,0.0008439485],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002901426,"about_ca_system_score_gemma":0.0003845788,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001312358,"about_ca_topic_score_gemma":0.002527112,"domain_scores_codex":[0.9997109,0.00006062933,0.00004187573,0.00004701471,0.00009271188,0.00004698185],"domain_scores_gemma":[0.9998467,0.00003558995,0.00002471124,0.00002445201,0.00002425793,0.00004423661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002265055,0.001201353,0.000962311,0.0003607928,0.00008794968,0.0001731952,0.0000587264,0.0008405076,0.9756409,0.0001862967,0.0009130639,0.01730992],"study_design_scores_gemma":[0.0002882706,0.005106606,0.005623522,0.00002262913,0.0001083402,0.000360263,0.00004641638,0.001538411,0.9808655,0.00004793284,0.005979977,0.00001216132],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9845851,0.005515066,0.002015914,0.0003011534,0.0001092604,0.0002203079,0.002142722,0.0002703144,0.004840202],"genre_scores_gemma":[0.9841635,0.003822896,0.004613981,0.0001022896,0.00003070505,0.000186339,0.002946869,0.00005319785,0.004080232],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003527972,"threshold_uncertainty_score":0.01180226,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05407916852333192,"score_gpt":0.3326405012719028,"score_spread":0.2785613327485709,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}