{"id":"W2604247578","doi":"10.1158/1557-3125.dnarepair16-b36","title":"Abstract B36: Targeting BRCA1 through natural HSP90 inhibitors to reverse platinum resistance in TNBC","year":2017,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Celastrol; Cancer research; Triple-negative breast cancer; Carboplatin; Hsp90; DNA damage; Breast cancer; DNA repair; Heat shock protein; Biology; Chemotherapy; Cancer; Medicine; Cisplatin; Apoptosis; DNA; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001222429,0.0002570488,0.0003492677,0.0001922719,0.0001095973,0.0002144544,0.0002878818,0.0002230516,0.001804414],"category_scores_gemma":[0.00007307651,0.00008851242,0.0002025765,0.0001858237,0.0001719428,0.0001604226,0.0001724681,0.000596766,0.0005025539],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003202555,"about_ca_system_score_gemma":0.000362399,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007081773,"about_ca_topic_score_gemma":0.001153076,"domain_scores_codex":[0.9999433,0.000009065781,0.000006994578,0.00001205914,0.0000129552,0.00001558031],"domain_scores_gemma":[0.9999571,0.000003453052,0.000007942856,0.000005465713,0.000005705942,0.00002028713],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001962902,0.0007546401,0.0003725284,0.0003040302,0.00003926162,0.00008160715,0.0000322911,0.0006401153,0.9779345,0.0002446705,0.00057481,0.01705851],"study_design_scores_gemma":[0.0009225034,0.009609768,0.004841408,0.00002983831,0.00008987691,0.0008202001,0.00002846301,0.001402097,0.9712398,0.0001253609,0.01087716,0.00001353538],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909791,0.004074108,0.001825103,0.0002797698,0.00007892263,0.0001872423,0.0006653178,0.0001379287,0.001772652],"genre_scores_gemma":[0.9905686,0.002321133,0.003321984,0.000115187,0.00001499562,0.00008793282,0.0007825798,0.00001945366,0.002768257],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001804414,"threshold_uncertainty_score":0.006036341,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04036369876631337,"score_gpt":0.397013913130472,"score_spread":0.3566502143641586,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}