{"id":"W2604267264","doi":"10.1073/pnas.1613203114","title":"Effects of systemic multiexon skipping with peptide-conjugated morpholinos in the heart of a dog model of Duchenne muscular dystrophy","year":2017,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":116,"is_retracted":false,"has_abstract":true,"ca_institutions":"Muscular Dystrophy Canada; University of Alberta","funders":"Japan Society for the Promotion of Science; Medical Research Council; Canadian Institutes of Health Research; Binghamton University; National Center of Neurology and Psychiatry; National Institutes of Health; Muscular Dystrophy Canada; Canada Foundation for Innovation; Ministry of Health, Labour and Welfare; University of Alberta; Women and Children's Health Research Institute; Children's Health Research Institute","keywords":"Morpholino; Duchenne muscular dystrophy; Conjugated system; mdx mouse; Medicine; Internal medicine; Muscular dystrophy; Dystrophin; Cardiology; Chemistry; Zebrafish; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006766155,0.00007833415,0.0001916066,0.00006197242,0.00009022989,0.000004486572,0.0007139475,0.00009029974,4.388588e-7],"category_scores_gemma":[0.0004454881,0.0000451014,0.0000763885,0.0001224178,0.001054251,0.0000239478,0.00009731527,0.00008327815,4.735665e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003975232,"about_ca_system_score_gemma":0.00004290878,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004583675,"about_ca_topic_score_gemma":3.224109e-7,"domain_scores_codex":[0.9990864,0.00001422415,0.0002688202,0.0001712903,0.0003602485,0.00009895804],"domain_scores_gemma":[0.9990572,0.00004433393,0.0006244232,0.00002899438,0.0002325605,0.00001245177],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008678542,0.00006424628,0.006241298,0.0003391957,0.00002291168,4.112274e-9,0.0001814395,0.00253167,0.9893801,0.001114654,0.00002176574,0.00001588985],"study_design_scores_gemma":[0.0005453093,0.0001737472,0.08241473,0.0002900721,0.0000184164,0.000002815214,0.000210718,0.002878509,0.911666,0.001744475,0.000001490876,0.00005366359],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990979,0.0001835842,0.000005813079,0.0002228175,0.000006340066,0.0002414017,0.000009372264,8.871882e-7,0.000231917],"genre_scores_gemma":[0.9994218,0.00003746134,0.0004564171,0.00004797977,0.00001400784,0.00001228598,3.518034e-7,0.000002685826,0.000007013622],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07771409,"threshold_uncertainty_score":0.3884434,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01886004068231673,"score_gpt":0.2754602788346971,"score_spread":0.2566002381523804,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}