{"id":"W2604281987","doi":"10.1016/j.celrep.2017.03.036","title":"Lineage-Specific Differentiation Is Influenced by State of Human Pluripotency","year":2017,"lang":"en","type":"article","venue":"Cell Reports","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Induced pluripotent stem cell; Biology; Germ layer; Homeobox protein NANOG; Lineage (genetic); Cellular differentiation; Cell biology; Embryonic stem cell; Computational biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001174621,0.00009285788,0.00006861314,0.00007477275,0.00006528036,0.0003028821,0.00005290715,0.00008746654,0.0007353906],"category_scores_gemma":[0.0001603642,0.00007025387,0.00006596641,0.00006600719,0.0001239284,0.0001279642,0.0001395114,0.0001683488,0.0001606988],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006895172,"about_ca_system_score_gemma":0.0001075857,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001138375,"about_ca_topic_score_gemma":0.0002148134,"domain_scores_codex":[0.9999114,0.00001942056,0.00001270838,0.00002003472,0.00002337309,0.00001294198],"domain_scores_gemma":[0.999933,0.00002384267,0.00001445084,0.00001154688,0.000008540468,0.000008560185],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002407963,0.000003951232,0.0007045977,0.00001342336,0.000001710703,0.00003085088,0.00002402504,0.00003888797,0.9964107,0.0002326272,0.00001569196,0.002499518],"study_design_scores_gemma":[0.000003061325,0.00009249432,0.007316052,0.000006093807,0.000008272138,0.0002879776,0.00003159781,0.0004372793,0.9894099,0.000140446,0.002263636,0.00000320225],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923977,0.001006474,0.00411711,0.00005360971,0.00001164439,0.00001402649,0.0001980032,0.00004339373,0.002158061],"genre_scores_gemma":[0.9970042,0.0006602045,0.001224634,0.00002707073,0.000003993649,0.0000103599,0.0001505628,0.000007599037,0.0009112203],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007353906,"threshold_uncertainty_score":0.002460182,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01414383452824819,"score_gpt":0.2740953978710768,"score_spread":0.2599515633428287,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}