{"id":"W2604281987","doi":"10.1016/j.celrep.2017.03.036","title":"Lineage-Specific Differentiation Is Influenced by State of Human Pluripotency","year":2017,"lang":"en","type":"article","venue":"Cell Reports","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Induced pluripotent stem cell; Biology; Germ layer; Homeobox protein NANOG; Lineage (genetic); Cellular differentiation; Cell biology; Embryonic stem cell; Computational biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002291768,0.0001437423,0.0001712979,0.00004020674,0.0002324104,0.00006445,0.0002850821,0.000103297,0.00006641692],"category_scores_gemma":[0.00005032528,0.0001387071,0.0001000446,0.00002712365,0.0001342267,0.0000090377,0.0002261786,0.00009740484,0.000009905089],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001331117,"about_ca_system_score_gemma":0.00004466801,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005139072,"about_ca_topic_score_gemma":0.000008311983,"domain_scores_codex":[0.9985647,0.0000324054,0.0004187946,0.0004360476,0.0002960655,0.0002520132],"domain_scores_gemma":[0.9979405,0.000004462869,0.0005628521,0.001222128,0.0001713254,0.00009877253],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001455481,0.00008189334,0.01083878,0.00004046747,0.00001758874,0.00003925249,0.00003920066,0.000006067401,0.9803063,7.69945e-7,0.007603017,0.001012151],"study_design_scores_gemma":[0.0002330872,0.0001117289,0.02600027,0.00001384977,0.000006557004,0.000009266133,0.000005002912,0.00001165918,0.9545848,0.00007110741,0.01881214,0.0001405085],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993726,0.0006711765,0.0002486043,0.00003593152,0.0001473645,0.0002086308,0.00001904537,0.000008134417,0.004935184],"genre_scores_gemma":[0.9875334,0.0004577014,0.00006264167,0.00002105871,0.00006366653,0.00001131864,0.0001711864,0.00002259618,0.01165647],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02572144,"threshold_uncertainty_score":0.5656312,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01414383452824819,"score_gpt":0.2740953978710768,"score_spread":0.2599515633428287,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}