{"id":"W2604303638","doi":"10.1158/1557-3125.dnarepair16-pr06","title":"Abstract PR06: Targeted chemotherapy for Homologous Repair Defects (HRD) in molecularly profiled cancer patients","year":2017,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Olaparib; Ovarian cancer; Medicine; Cancer research; PARP inhibitor; Synthetic lethality; Cancer; Targeted therapy; Gene mutation; Homologous recombination; Kinase; Mutation; Oncology; Gene; DNA repair; Bioinformatics; Internal medicine; Biology; Genetics; Poly ADP ribose polymerase","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008693545,0.0002450866,0.000587915,0.0003074305,0.000368626,0.000546283,0.0005358439,0.0005795463,0.009092462],"category_scores_gemma":[0.0008402682,0.0001632354,0.0004872632,0.0003323178,0.0002642794,0.0003966744,0.0005004696,0.001496982,0.002160463],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008287951,"about_ca_system_score_gemma":0.0008293011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004007067,"about_ca_topic_score_gemma":0.0007691266,"domain_scores_codex":[0.9996227,0.0001471804,0.00002986376,0.00009407633,0.00005705082,0.00004904066],"domain_scores_gemma":[0.999519,0.00009015788,0.0000856107,0.00005668411,0.00004906709,0.0001994187],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.08147071,0.008826075,0.02425894,0.0007948923,0.0002494535,0.0008388161,0.0001840904,0.004267451,0.07096333,0.002523161,0.08938318,0.7162398],"study_design_scores_gemma":[0.07227425,0.2499204,0.2335046,0.0006207943,0.0007737069,0.01366582,0.000224,0.01698673,0.1349193,0.00379358,0.2730994,0.0002174802],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.9198148,0.0108664,0.008589775,0.004467668,0.0006257466,0.004981382,0.01017009,0.001721111,0.038763],"genre_scores_gemma":[0.9585112,0.003219219,0.01224009,0.00298489,0.0002183371,0.002344788,0.009431541,0.0001778019,0.010872],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.009092462,"threshold_uncertainty_score":0.03041726,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02778214807525649,"score_gpt":0.3643910729977251,"score_spread":0.3366089249224686,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}