{"id":"W2604304527","doi":"10.1158/1557-3125.dnarepair16-a16","title":"Abstract A16: Potent and selective ATR inhibitors for the treatment of homologous-recombination deficient and PARPi-resistant cancers","year":2017,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Homologous recombination; Synthetic lethality; Cancer research; DNA damage; CHEK1; Biology; G2-M DNA damage checkpoint; RAD51; Cancer; Kinase; DNA repair; Neuroblastoma RAS viral oncogene homolog; Mutation; KRAS; Chemistry; DNA; Genetics; Cell cycle; Cell cycle checkpoint; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002823752,0.0006778587,0.0003747708,0.0006508649,0.0001574993,0.0002707552,0.0005633445,0.0004473054,0.002851855],"category_scores_gemma":[0.0001136009,0.0002175442,0.000452495,0.0002402401,0.0001660936,0.0002616754,0.0002427338,0.0009261192,0.001487573],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001863595,"about_ca_system_score_gemma":0.0003626753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002750747,"about_ca_topic_score_gemma":0.0006397939,"domain_scores_codex":[0.9999163,0.00001963323,0.00001073749,0.00001566063,0.0000222536,0.00001532158],"domain_scores_gemma":[0.9999229,0.000007247008,0.00001797916,0.000009395674,0.00000853833,0.00003390441],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002428977,0.001373415,0.0005248234,0.0005403108,0.00009911651,0.0005074432,0.00004842748,0.001347818,0.9018632,0.0009216666,0.004012676,0.08633209],"study_design_scores_gemma":[0.004418166,0.02445323,0.005991161,0.0001327433,0.0002016457,0.005295175,0.00003253231,0.002244311,0.8744676,0.0004560525,0.08224984,0.00005765029],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.8896618,0.06475718,0.01468574,0.0009099845,0.0009163449,0.001778697,0.004411684,0.001234355,0.02164422],"genre_scores_gemma":[0.9359159,0.02577331,0.01041889,0.0003725995,0.0001456423,0.000740226,0.003175824,0.0001171615,0.02334055],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.002851855,"threshold_uncertainty_score":0.009540379,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03584906597793027,"score_gpt":0.3589718755488449,"score_spread":0.3231228095709146,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}