{"id":"W2604312687","doi":"10.1016/j.vaccine.2017.03.039","title":"Development of a DNA vaccine expressing a secreted HIV-1 gp41 ectodomain that includes the membrane-proximal external region","year":2017,"lang":"en","type":"article","venue":"Vaccine","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Ectodomain; Gp41; DNA vaccination; Virology; DNA; Biology; Cell biology; Recombinant DNA; Genetics; Gene; Epitope; Antigen; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003310122,0.0005404943,0.0003160281,0.0002789502,0.0001928701,0.000484202,0.0004750655,0.0006616946,0.000973086],"category_scores_gemma":[0.0002419921,0.0002328069,0.0005019492,0.0001324439,0.0003489354,0.0004133644,0.0003293781,0.001416801,0.0003702381],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004868715,"about_ca_system_score_gemma":0.0007173964,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005323577,"about_ca_topic_score_gemma":0.000510783,"domain_scores_codex":[0.9998497,0.00002081667,0.000009291095,0.00002944583,0.00004411906,0.00004664704],"domain_scores_gemma":[0.9998969,0.00001847763,0.00002010701,0.000009411636,0.00002358468,0.00003152005],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001731152,0.0003348457,0.0001852694,0.00007765919,0.00001699974,0.00009107064,0.00003063043,0.001055758,0.9898353,0.0007837981,0.000120998,0.007294516],"study_design_scores_gemma":[0.0003050832,0.002664711,0.0005872316,0.00002002108,0.000070298,0.0003202347,0.00003639921,0.005008981,0.9841895,0.000279139,0.006506651,0.00001183346],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9453122,0.001747341,0.04749597,0.0006296833,0.0002747262,0.0007528194,0.0003822483,0.0001711558,0.003233753],"genre_scores_gemma":[0.9554603,0.001453582,0.03770025,0.0002300193,0.00003671352,0.0002341837,0.000926543,0.0000311129,0.003927222],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000973086,"threshold_uncertainty_score":0.003532469,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03590083600787333,"score_gpt":0.2818983122727253,"score_spread":0.245997476264852,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}