{"id":"W2604362788","doi":"10.1080/14756366.2017.1308928","title":"Design, synthesis and evaluation of<sup>18</sup>F-labeled cationic carbonic anhydrase IX inhibitors for PET imaging","year":2017,"lang":"en","type":"article","venue":"Journal of Enzyme Inhibition and Medicinal Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Cationic polymerization; Carbonic anhydrase; Tumor hypoxia; Enzyme; Pet imaging; Imaging agent; Specific activity; In vivo; Biochemistry; Nuclear medicine; Positron emission tomography; Medicine; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001671216,0.0001708775,0.0002573056,0.00006780001,0.0002324693,0.00005199133,0.00008354257,0.000110466,0.00006281717],"category_scores_gemma":[0.001466592,0.0001566657,0.00009807792,0.00003628192,0.0002271831,0.00004459321,0.00004008123,0.0001500776,2.876673e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005143169,"about_ca_system_score_gemma":0.0002701062,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007127978,"about_ca_topic_score_gemma":0.000001973999,"domain_scores_codex":[0.9986299,0.00007940827,0.0005097651,0.0002325854,0.0003802511,0.0001681507],"domain_scores_gemma":[0.9980367,0.00006946553,0.0007450883,0.00022941,0.0007591153,0.0001602129],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003134201,0.00007329298,0.0003692123,0.0001459944,0.00005259971,0.000006073069,0.00007168426,0.0001254282,0.9909939,0.000008823785,0.004697374,0.003142226],"study_design_scores_gemma":[0.002885762,0.0002349241,0.0002476237,0.0004238196,0.0003102032,0.000556048,0.0004463958,0.00360091,0.9901041,0.0002145202,0.0008051828,0.0001704947],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940736,0.002059635,0.002099019,0.0007736887,0.0001139211,0.0002354809,0.00001579415,0.000005011495,0.0006238807],"genre_scores_gemma":[0.9980913,0.000461116,0.000486278,0.0001225783,0.0006582133,0.00002802272,0.00003656043,0.00001785822,0.00009801057],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004017794,"threshold_uncertainty_score":0.6388643,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02644847747718487,"score_gpt":0.2964178657608086,"score_spread":0.2699693882836237,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}