{"id":"W2604376168","doi":"10.1038/srep45983","title":"Inhibition of Pyruvate Kinase M2 Markedly Reduces Chemoresistance of Advanced Bladder Cancer to Cisplatin","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":104,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"NIH Clinical Center; National Cancer Institute; School of Medicine, New York University; Cancer Research UK; National Taiwan University; York University; Office of Research and Development; U.S. Department of Veterans Affairs","keywords":"Cisplatin; PKM2; Pyruvate kinase; Cancer research; Apoptosis; Kinase; Cell growth; Pharmacology; Chemistry; Metastasis; Warburg effect; Downregulation and upregulation; Cancer cell; Medicine; Cancer; Glycolysis; Chemotherapy; Internal medicine; Biochemistry; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001105402,0.0002979161,0.0005190958,0.0002379715,0.0001401436,0.0002650205,0.0002175394,0.0002282195,0.0009042597],"category_scores_gemma":[0.000126123,0.0001232456,0.0002257956,0.00022215,0.0002235642,0.0002315305,0.000205436,0.0006723913,0.0001624414],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002407941,"about_ca_system_score_gemma":0.0003697197,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006151265,"about_ca_topic_score_gemma":0.001017856,"domain_scores_codex":[0.999897,0.00001989855,0.00001106562,0.00001401588,0.00002603237,0.00003194905],"domain_scores_gemma":[0.9999353,0.000009941296,0.00001449552,0.000008844528,0.000008430256,0.00002297612],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004209471,0.0002040649,0.0002642981,0.00009743468,0.00001499912,0.00003175255,0.00001867653,0.0002541019,0.9926617,0.00008795625,0.0001602132,0.005783852],"study_design_scores_gemma":[0.00009980272,0.002109371,0.006716226,0.00001200548,0.00004895188,0.0001626441,0.00003079625,0.001717133,0.9857078,0.00006807258,0.003319606,0.000007627727],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948869,0.002156492,0.001254315,0.0001478277,0.00005379315,0.00003554944,0.0001400884,0.0001361513,0.00118881],"genre_scores_gemma":[0.9967249,0.001226013,0.0007016443,0.00004488222,0.000009829517,0.0000333031,0.0002276794,0.00001285917,0.001018833],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009042597,"threshold_uncertainty_score":0.003025055,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01952090601170939,"score_gpt":0.3141570156136392,"score_spread":0.2946361096019298,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}