{"id":"W2604379507","doi":"10.1158/1557-3125.dnarepair16-ia12","title":"Abstract IA12: Poisoning cancer with oxidized nucleotides by targeting MTH1","year":2017,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"DNA damage; Cancer cell; DNA repair; DNA; Cancer; Biology; Cancer research; Apoptosis; Cell biology; Biochemistry; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008935875,0.0002611156,0.0002379014,0.0000749238,0.000806721,0.0003362399,0.0009364391,0.000188366,0.0002427133],"category_scores_gemma":[0.0002831634,0.0002345512,0.0001094266,0.0001041255,0.0003208636,0.00001919562,0.0004628163,0.0004396183,0.00002376182],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001058532,"about_ca_system_score_gemma":0.0003680045,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003059719,"about_ca_topic_score_gemma":0.0004160428,"domain_scores_codex":[0.9971893,0.0001324964,0.0002223697,0.0007948248,0.0007651598,0.0008958167],"domain_scores_gemma":[0.9981472,0.00001766512,0.0001637694,0.001058383,0.0003823306,0.0002306133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002401585,0.00004276318,0.001460166,0.00004749952,0.0001396843,0.00007428079,0.00004181797,0.00008418308,0.9869339,0.0000625445,0.007727904,0.003145128],"study_design_scores_gemma":[0.0009246853,0.0001657895,0.0007565275,0.0001200973,0.0000149436,0.000004093614,0.00009096131,0.00005713361,0.9679708,0.00006891115,0.02950424,0.000321776],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989597,0.005161936,0.0004319353,0.001141836,0.0001363142,0.0004389661,0.00005567604,0.00003409834,0.003002245],"genre_scores_gemma":[0.9957448,0.0007605621,0.001124164,0.0001885516,0.0002134778,0.0003540156,0.00004773959,0.000109841,0.001456808],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02177634,"threshold_uncertainty_score":0.9564719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03006471798108401,"score_gpt":0.3682894369810254,"score_spread":0.3382247189999414,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}