{"id":"W2604419444","doi":"10.1158/1557-3125.dnarepair16-a11","title":"Abstract A11: RB localizes to DNA double strand breaks and promotes DNA end resection and homologous recombination through the recruitment of BRG1","year":2017,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Genome instability; Homologous recombination; E2F; Chromatin; Molecular biology; DNA repair; Non-homologous end joining; Biology; DNA damage; DNA; ARID1A; Cancer research; Cell cycle; Mutation; Chemistry; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009513182,0.0005032044,0.0002337718,0.0002809801,0.0002116142,0.0003184073,0.0003149234,0.0003528299,0.003731637],"category_scores_gemma":[0.00006902758,0.000174704,0.0002587477,0.0001519067,0.0002300456,0.0001352354,0.0002652776,0.0004674198,0.002132983],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003004095,"about_ca_system_score_gemma":0.0001526887,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006152499,"about_ca_topic_score_gemma":0.0005672938,"domain_scores_codex":[0.9998504,0.00001887221,0.0000134083,0.000047602,0.00004065074,0.00002908831],"domain_scores_gemma":[0.999905,0.000007683542,0.0000343917,0.00001067264,0.00000741758,0.00003481024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003049829,0.000005755302,0.00004810398,0.00001386765,0.000001447583,0.00002758822,0.000002124965,0.00001598009,0.9994411,0.00005356064,0.00004855423,0.0003113969],"study_design_scores_gemma":[0.00001010597,0.00007698605,0.003978549,0.000005348561,0.000007232918,0.0004152526,0.00001009792,0.0003644038,0.9907734,0.00003820558,0.004317159,0.000003163386],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9698131,0.005656132,0.01502293,0.000388477,0.0001464802,0.00004739074,0.002455474,0.000897766,0.005572265],"genre_scores_gemma":[0.9791297,0.001070986,0.00288511,0.00009343454,0.00002240817,0.0000301524,0.002356328,0.0001190151,0.01429271],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003731637,"threshold_uncertainty_score":0.0124836,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.105699145804958,"score_gpt":0.4182570651108149,"score_spread":0.3125579193058569,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}