{"id":"W2604428063","doi":"10.1016/j.str.2017.03.004","title":"Bound Waters Mediate Binding of Diverse Substrates to a Ubiquitin Ligase","year":2017,"lang":"en","type":"article","venue":"Structure","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; National Institutes of Health; National Science Foundation","keywords":"Isothermal titration calorimetry; Chemistry; Degron; Histidine; Arginine; Lysine; Stereochemistry; Ubiquitin ligase; Peptide; Biochemistry; Amino acid; Binding site; Plasma protein binding; Biophysics; Ubiquitin; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008653504,0.0001371053,0.0001375513,0.00003511117,0.0002134899,0.00006230055,0.0003653324,0.0001341018,0.00007521638],"category_scores_gemma":[0.0001065287,0.0001164961,0.00006506041,0.00002493659,0.0001097267,0.00000553315,0.0001960845,0.00007757889,0.00001151074],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000630854,"about_ca_system_score_gemma":0.00004196759,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000365469,"about_ca_topic_score_gemma":0.00005857636,"domain_scores_codex":[0.9992548,0.00002082815,0.0001333481,0.0002492444,0.0001095778,0.0002321574],"domain_scores_gemma":[0.9992249,0.000004260366,0.000120515,0.0004761377,0.00005560459,0.0001186096],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006231664,0.000005404017,0.007168004,0.00003023146,0.00002836033,0.00000774812,0.0002362518,0.000006206832,0.9906092,0.00008030116,0.0005150096,0.001250909],"study_design_scores_gemma":[0.0003101176,0.000135866,0.006023332,0.00002259772,0.00001279095,0.000007458372,0.0001611524,0.000001436423,0.98958,0.0003205574,0.003275016,0.0001496919],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981084,0.00006083119,0.000009854771,0.0001659957,0.0002562024,0.0001629881,0.0003032672,0.000007882327,0.0009245379],"genre_scores_gemma":[0.9987792,0.00001927653,0.0004390895,0.0001040222,0.0002476044,0.000005798349,0.00009365888,0.00001555946,0.0002957402],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002760006,"threshold_uncertainty_score":0.4750574,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01598467707580136,"score_gpt":0.2686195688422559,"score_spread":0.2526348917664545,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}