{"id":"W2604428063","doi":"10.1016/j.str.2017.03.004","title":"Bound Waters Mediate Binding of Diverse Substrates to a Ubiquitin Ligase","year":2017,"lang":"en","type":"article","venue":"Structure","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; National Institutes of Health; National Science Foundation","keywords":"Isothermal titration calorimetry; Chemistry; Degron; Histidine; Arginine; Lysine; Stereochemistry; Ubiquitin ligase; Peptide; Biochemistry; Amino acid; Binding site; Plasma protein binding; Biophysics; Ubiquitin; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003923353,0.0004080778,0.0005821779,0.0001920271,0.0009536608,0.001363469,0.0007089651,0.0007117853,0.002963243],"category_scores_gemma":[0.0007918171,0.0003421122,0.0003809703,0.0002377318,0.0008971231,0.001762772,0.001158785,0.0006896004,0.000620966],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007598299,"about_ca_system_score_gemma":0.0004600337,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001733815,"about_ca_topic_score_gemma":0.002292959,"domain_scores_codex":[0.9996504,0.00005185474,0.00001518314,0.00007096191,0.00009771528,0.0001139626],"domain_scores_gemma":[0.9997701,0.00006045116,0.0000302162,0.00003341625,0.00003543361,0.00007033972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007997102,0.00006133243,0.001871929,0.00009498165,0.00004157359,0.0003665896,0.0001656821,0.0007058811,0.9783386,0.01222486,0.0003262562,0.005002571],"study_design_scores_gemma":[0.00002958386,0.0001360781,0.001778699,0.000006513609,0.00002060997,0.0002250563,0.0002210215,0.004112961,0.9889599,0.001958468,0.002527531,0.0000236409],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855331,0.0009129474,0.009080839,0.0002567561,0.00005730707,0.00003127115,0.00008332438,0.000133285,0.003911188],"genre_scores_gemma":[0.9943498,0.0002512939,0.002310699,0.00005595922,0.00001073974,0.000007326027,0.00009480073,0.000034598,0.002884811],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002963243,"threshold_uncertainty_score":0.009913027,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01598467707580136,"score_gpt":0.2686195688422559,"score_spread":0.2526348917664545,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}