{"id":"W2604428127","doi":"10.1208/s12249-017-0768-3","title":"Effects of Chamber Pressure and Partial Pressure of Water Vapor on Secondary Drying in Lyophilization","year":2017,"lang":"en","type":"article","venue":"AAPS PharmSciTech","topic":"Protein purification and stability","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"Privy Council Office","funders":"Pfizer Pharmaceuticals","keywords":"Vapor pressure; Vapour pressure of water; Water vapor; Partial pressure; Water content; Chemistry; Moisture; Aqueous solution; Chamber pressure; Chemical engineering; Analytical Chemistry (journal); Chromatography; Materials science; Organic chemistry; Oxygen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002044606,0.0000809444,0.0001246324,0.0000274284,0.00005295581,0.00001148017,0.0001118952,0.0001065027,0.00002167784],"category_scores_gemma":[0.0001052186,0.00006483384,0.00002893396,0.00001597326,0.00009670579,0.000008694703,0.00008521811,0.00006726094,6.568548e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000001495466,"about_ca_system_score_gemma":0.00001668359,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002067722,"about_ca_topic_score_gemma":0.000004193041,"domain_scores_codex":[0.9993759,0.00005024211,0.0001615022,0.000221972,0.00008290086,0.0001075315],"domain_scores_gemma":[0.9994594,0.00000956752,0.0001008988,0.0003527185,0.00004767769,0.00002969332],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001394124,0.0001063869,0.005433519,0.0003368455,0.00003338976,0.0000011119,0.0001440367,0.00001795147,0.9898737,0.00009235626,0.00002802835,0.003793247],"study_design_scores_gemma":[0.0007515501,0.00008964692,0.03188419,0.00002504848,0.00002195793,9.84095e-7,0.000003397463,0.0001125747,0.9590458,0.0001127226,0.007881445,0.00007064532],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976186,0.001276996,0.0001045033,0.0001104362,0.00006887969,0.0003532897,0.00002105049,0.000004180043,0.0004420262],"genre_scores_gemma":[0.9995342,0.00008446788,0.00003685031,0.00003087646,0.00003802825,0.00002950643,0.00002397275,0.000007543488,0.000214476],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03082787,"threshold_uncertainty_score":0.2643847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008222005264280689,"score_gpt":0.2622236196891423,"score_spread":0.2540016144248616,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}