{"id":"W2604439647","doi":"10.1158/1557-3125.dnarepair16-b26","title":"Abstract B26: Development of a proximity ligation assay for the detection of PARP-1 trapped to chromatin","year":2017,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"PARP1; Poly ADP ribose polymerase; PARP inhibitor; Chromatin; Synthetic lethality; Cancer research; Context (archaeology); Chemistry; DNA repair; Biology; Computational biology; Cell biology; DNA; Polymerase; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002022632,0.00008952666,0.0002021779,0.0001297107,0.000336338,0.00002751405,0.0002435969,0.00007121492,0.00005547672],"category_scores_gemma":[0.0004381789,0.00006827099,0.0000830305,0.0001648387,0.0001659087,0.00006084071,0.00004886236,0.0001919832,0.000004457033],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002624406,"about_ca_system_score_gemma":0.0006157521,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003730197,"about_ca_topic_score_gemma":0.0002434604,"domain_scores_codex":[0.9983681,0.00006669571,0.0003277968,0.0002209361,0.0007634122,0.0002529872],"domain_scores_gemma":[0.9983776,0.0001280814,0.0001871587,0.0005737846,0.000649665,0.00008376571],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00056719,0.00006687904,0.0002596414,0.0002753655,0.00009145457,0.000001523801,0.0006682663,0.00002682835,0.8837826,0.00003925574,0.0001131098,0.1141079],"study_design_scores_gemma":[0.001150363,0.0001780137,0.04994342,0.0003259073,0.00001524721,0.000001162102,0.00008328033,0.0002010989,0.9442682,0.000188744,0.003582542,0.00006205454],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9481772,0.0004624219,0.04557253,0.002903465,0.00009587633,0.002288514,0.00002037634,0.00001304777,0.0004666372],"genre_scores_gemma":[0.9962515,0.0000418506,0.001971471,0.00006003148,0.00007266441,0.001488389,0.000004454299,0.0000215491,0.00008807783],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1140458,"threshold_uncertainty_score":0.278401,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1337399826429144,"score_gpt":0.4563149747341596,"score_spread":0.3225749920912452,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}