{"id":"W2604491809","doi":"10.1158/1557-3125.dnarepair16-b33","title":"Abstract B33: PARP-dependent co-modulation of DNA repair and microglial activity as a dual-pronged anti-glioblastoma treatment strategy","year":2017,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"CancerCare Manitoba; Research Institute in Oncology and Hematology; University of Manitoba","funders":"","keywords":"Cancer research; DNA repair; Microglia; Poly ADP ribose polymerase; Radioresistance; Cancer; DNA damage; Temozolomide; Cancer cell; Brain tumor; Immune system; PARP inhibitor; Medicine; Radiation therapy; Biology; Immunology; Glioma; Inflammation; Pathology; Internal medicine; DNA; Polymerase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001008745,0.0003981662,0.0002634367,0.0001532467,0.0001132278,0.0002782152,0.0002474253,0.0003207603,0.003279524],"category_scores_gemma":[0.00006790661,0.0001108781,0.0002244314,0.0001273846,0.0001038562,0.0001823033,0.000192917,0.0006826945,0.0007382847],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001550002,"about_ca_system_score_gemma":0.0002337038,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003114328,"about_ca_topic_score_gemma":0.000464536,"domain_scores_codex":[0.9999355,0.000008842927,0.00000430458,0.00001264745,0.00001469229,0.00002405174],"domain_scores_gemma":[0.9999661,0.000003278002,0.000009659239,0.000002985358,0.000006958803,0.00001101224],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009596319,0.0003588934,0.0001918492,0.0004426213,0.00003071165,0.0001555631,0.00002564503,0.0003619519,0.9720219,0.0004634391,0.001439742,0.0235481],"study_design_scores_gemma":[0.0003799965,0.005957303,0.002962964,0.00005120677,0.00009745208,0.0009256168,0.00003508562,0.002006758,0.9667003,0.0002573119,0.02060436,0.00002174767],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9536958,0.02204795,0.01193712,0.001246807,0.0004853535,0.0004006579,0.001094846,0.0004396465,0.0086519],"genre_scores_gemma":[0.9849107,0.005094443,0.004070233,0.0003152354,0.00006247476,0.0001790136,0.0005614498,0.00002164234,0.004784824],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003279524,"threshold_uncertainty_score":0.01097113,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09384369509480044,"score_gpt":0.4551935700639455,"score_spread":0.3613498749691451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}