{"id":"W2604502265","doi":"10.1200/jco.2004.22.90140.7038","title":"Randomized phase II-III study of matrix metalloproteinase inhibitor (MMPI) BMS-275291 in combination with paclitaxel (P) and carboplatin (C) in advanced non-small cell lung cancer (NSCLC): NCIC-CTG BR.18","year":2004,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Bristol-Myers Squibb (Canada)","funders":"","keywords":"Medicine; Internal medicine; Neutropenia; Clinical endpoint; Carboplatin; Interim analysis; Febrile neutropenia; Lung cancer; Toxicity; Placebo; Gastroenterology; Phases of clinical research; Surgery; Chemotherapy; Oncology; Randomized controlled trial; Cisplatin; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001607899,0.002225968,0.002997693,0.0006613535,0.0005366075,0.0009241042,0.001139823,0.001545592,0.006676052],"category_scores_gemma":[0.001129703,0.0008662216,0.001028326,0.0005837462,0.001311978,0.0008342496,0.0004378842,0.002846449,0.001586183],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001326254,"about_ca_system_score_gemma":0.00264613,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001881719,"about_ca_topic_score_gemma":0.00459698,"domain_scores_codex":[0.9995555,0.0002316017,0.00002081428,0.00006635558,0.00004183135,0.00008385875],"domain_scores_gemma":[0.9992987,0.0001208403,0.0001369766,0.00005277345,0.0000476278,0.000342999],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9400176,0.03035713,0.001136487,0.0004372323,0.0004707292,0.00007847804,0.00007135246,0.0006342461,0.008760273,0.0001581391,0.001830987,0.01604729],"study_design_scores_gemma":[0.8988112,0.0978412,0.001349071,0.00001098022,0.0001602426,0.00004149397,0.00001501511,0.00035223,0.0006732367,0.00007701918,0.0006592548,0.000008993284],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9811261,0.001683376,0.000819041,0.0006378962,0.0003384941,0.01116777,0.001883727,0.0002204373,0.002122999],"genre_scores_gemma":[0.9693055,0.002251578,0.002621356,0.001445889,0.0004185888,0.01419143,0.003040255,0.00005948911,0.006665904],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006676052,"threshold_uncertainty_score":0.02233362,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04040965542454393,"score_gpt":0.429095674913167,"score_spread":0.3886860194886231,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}