{"id":"W2604502265","doi":"10.1200/jco.2004.22.90140.7038","title":"Randomized phase II-III study of matrix metalloproteinase inhibitor (MMPI) BMS-275291 in combination with paclitaxel (P) and carboplatin (C) in advanced non-small cell lung cancer (NSCLC): NCIC-CTG BR.18","year":2004,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Bristol-Myers Squibb (Canada)","funders":"","keywords":"Medicine; Internal medicine; Neutropenia; Clinical endpoint; Carboplatin; Interim analysis; Febrile neutropenia; Lung cancer; Toxicity; Placebo; Gastroenterology; Phases of clinical research; Surgery; Chemotherapy; Oncology; Randomized controlled trial; Cisplatin; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00480288,0.000243669,0.003218521,0.000591563,0.00004308487,0.000009036598,0.0001058563,0.000293151,0.0000966718],"category_scores_gemma":[0.001408648,0.0001712058,0.0003856973,0.000531242,0.0002247444,0.0001838179,0.00005591448,0.001056905,6.38914e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002931282,"about_ca_system_score_gemma":0.001300845,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007196205,"about_ca_topic_score_gemma":0.002592259,"domain_scores_codex":[0.9945986,0.0007422823,0.003597103,0.0003181693,0.000478469,0.0002653826],"domain_scores_gemma":[0.9953607,0.001127571,0.002518806,0.0001909949,0.0004885594,0.000313406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7974046,0.08724327,0.04764573,0.0005113867,0.001688546,0.004541474,0.006538179,0.003202889,0.03001546,0.00007784983,0.0001579056,0.02097268],"study_design_scores_gemma":[0.9554461,0.02633832,0.008694801,0.001566067,0.00119158,0.0000615979,0.002323233,0.001346318,0.002609243,0.0001567516,0.00005278142,0.0002132562],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953039,0.0005601522,0.0003332433,0.001825945,0.0001141841,0.001484975,0.000005287698,0.000007061295,0.0003652299],"genre_scores_gemma":[0.9966743,0.000306521,0.002245059,0.0003521475,0.0001701945,0.00006383583,0.000004696152,0.00002102674,0.0001622262],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1580414,"threshold_uncertainty_score":0.698157,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04040965542454393,"score_gpt":0.429095674913167,"score_spread":0.3886860194886231,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}