{"id":"W2604503911","doi":"10.1002/ejoc.201700466","title":"Fluorine at the C5 Position of 2′‐Deoxyuridine Enhances Repair of a <i>O</i><sup>4</sup>‐Methyl Adduct by <i>O</i><sup>6</sup>‐Alkylguanine DNA Alkyltransferases","year":2017,"lang":"en","type":"article","venue":"European Journal of Organic Chemistry","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University","funders":"Fonds de recherche du Québec – Nature et technologies; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Chemistry; Nucleobase; Deoxyuridine; Thymine; Steric effects; DNA; Thymidine; Adduct; Stereochemistry; Guanine; Methyl group; Alkylation; Deoxyguanosine; Oligonucleotide; Biochemistry; Nucleotide; Gene; Organic chemistry; Group (periodic table)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002024402,0.000250824,0.0002697223,0.0001148722,0.00006725091,0.0002359931,0.0002044264,0.0002824703,0.0007353577],"category_scores_gemma":[0.0002270183,0.0001335962,0.0001973716,0.0001021578,0.0001700032,0.000173037,0.0001484092,0.0002480671,0.000145985],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001592253,"about_ca_system_score_gemma":0.0001278134,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006484622,"about_ca_topic_score_gemma":0.0007138291,"domain_scores_codex":[0.9998185,0.00004120877,0.00001552301,0.00003471716,0.00004760593,0.00004249605],"domain_scores_gemma":[0.9998507,0.00004282366,0.00004315332,0.00001353159,0.00002186979,0.00002785417],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009418862,0.00001624025,0.0001239916,0.00002187719,0.000003735969,0.00001160213,0.000008603772,0.00006535788,0.9989983,0.00001625731,0.000006057216,0.0006338668],"study_design_scores_gemma":[0.000003418418,0.0003718118,0.001504978,0.000001957835,0.000009150184,0.0000390043,0.000009521549,0.0004029683,0.9973215,0.000004518719,0.0003291398,0.000001968525],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981979,0.000667067,0.0006308975,0.00001157055,0.000005679826,0.000006499408,0.00003055305,0.00001857168,0.0004312775],"genre_scores_gemma":[0.9982943,0.0003045959,0.0007212172,0.000008663612,0.000002319118,0.000003995256,0.00008361783,0.000006463546,0.0005748685],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007353577,"threshold_uncertainty_score":0.002460063,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006987414997291154,"score_gpt":0.2190230145779762,"score_spread":0.212035599580685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}