{"id":"W2604513881","doi":"10.1016/j.jaci.2017.02.038","title":"Type 2 innate lymphoid cells disrupt bronchial epithelial barrier integrity by targeting tight junctions through IL-13 in asthmatic patients","year":2017,"lang":"en","type":"article","venue":"Journal of Allergy and Clinical Immunology","topic":"IL-33, ST2, and ILC Pathways","field":"Immunology and Microbiology","cited_by":268,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"Japan Society for the Promotion of Science; Merck Sharp and Dohme; Alimentary Health; European Commission; Japan Science and Technology Agency; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Kyorin Pharmaceutical; National Center for Child Health and Development; Torii Pharmaceutical; Allergopharma; GlaxoSmithKline; Mitsubishi Tanabe Pharma Corporation; Precursory Research for Embryonic Science and Technology; AstraZeneca; Canadian Institutes of Health Research; National Science Foundation","keywords":"Tight junction; Innate lymphoid cell; Paracellular transport; Immunology; Barrier function; Epithelium; Transplantation; Biology; Innate immune system; Cell biology; Chemistry; Pathology; Medicine; Immune system; Internal medicine; Permeability (electromagnetism)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002932364,0.0002374367,0.00048649,0.0001857259,0.0003766463,0.000601252,0.0002077945,0.0005444797,0.001594544],"category_scores_gemma":[0.0005300018,0.0001653972,0.000363119,0.000169513,0.0002273575,0.0003019866,0.0002160176,0.0008285737,0.0002028082],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000351812,"about_ca_system_score_gemma":0.0003901835,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006289489,"about_ca_topic_score_gemma":0.0011143,"domain_scores_codex":[0.9997352,0.00006963425,0.00002672231,0.00003832952,0.00004855555,0.00008165312],"domain_scores_gemma":[0.9998316,0.00003187623,0.00005614582,0.00001088569,0.0000171904,0.00005238225],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01324873,0.001280359,0.7278347,0.0004091439,0.0003649697,0.01638836,0.0005561436,0.0004932867,0.1700376,0.00107587,0.003408222,0.06490266],"study_design_scores_gemma":[0.000521832,0.00379959,0.9534406,0.0001153628,0.000590567,0.0170273,0.0008315928,0.001968844,0.01605818,0.0006777215,0.004945519,0.00002275377],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996579,0.001688487,0.0002251862,0.0003490584,0.00003243094,0.00001807253,0.00008280749,0.00001940505,0.001005584],"genre_scores_gemma":[0.9988606,0.0002974494,0.00008805795,0.0001750933,0.00003325439,0.00001188343,0.00008604295,0.000002854302,0.0004448625],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001594544,"threshold_uncertainty_score":0.005334258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01847673694297548,"score_gpt":0.2893774911712501,"score_spread":0.2709007542282746,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}