{"id":"W2604523348","doi":"10.1053/j.gastro.2017.03.049","title":"Efficacy and Safety of MEDI2070, an Antibody Against Interleukin 23, in Patients With Moderate to Severe Crohn’s Disease: A Phase 2a Study","year":2017,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":277,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials","funders":"","keywords":"Placebo; Medicine; Crohn's disease; Internal medicine; Gastroenterology; Adverse effect; Clinical trial; Cytokine; Clinical endpoint; Confidence interval; Immunology; Disease; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001659012,0.0002589501,0.0005091624,0.0001676271,0.000197771,0.00001992744,0.0003258736,0.00009276206,0.00003225589],"category_scores_gemma":[0.00004415501,0.0002067402,0.0000380417,0.00003665133,0.0002051125,0.0001221579,0.0001884023,0.0001307853,0.00001670135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003075138,"about_ca_system_score_gemma":0.00002568696,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000533303,"about_ca_topic_score_gemma":0.0006063136,"domain_scores_codex":[0.9983573,0.0003404952,0.0003402786,0.000488525,0.00004694192,0.0004264879],"domain_scores_gemma":[0.9989833,0.00003124205,0.0002050479,0.000619426,0.00006617899,0.00009483215],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.06742661,0.004014393,0.9177876,0.00001036524,0.0003302223,0.00008597813,0.001010602,0.00002670017,0.001397295,0.000003850912,0.00003219179,0.007874272],"study_design_scores_gemma":[0.0403523,0.005758629,0.9533261,0.00004827295,0.0001211867,0.000005422686,0.0001172569,0.000007862574,0.0001046172,0.000003955052,0.00003976746,0.0001146317],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983343,0.00005404298,0.00004384664,0.0001102322,0.0002403158,0.0009165222,0.000254006,0.00002056293,0.00002613448],"genre_scores_gemma":[0.9992857,0.00001181342,0.00005397659,0.0001218044,0.00001594259,0.00004423971,0.0003820802,0.00001978288,0.00006463622],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03553857,"threshold_uncertainty_score":0.8430619,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01178307712284571,"score_gpt":0.2720936123855986,"score_spread":0.2603105352627529,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}