{"id":"W2604552051","doi":"10.1200/jco.2014.32.15_suppl.6041","title":"Preoperative window-of-opportunity (WOO) study of dacomitinib (Dac) in patients (Pts) with resectable oral cavity squamous cell carcinoma (OCC): Generation of a gene expression signature (DGS) as a predictor of Dac activity.","year":2014,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Juravinski Cancer Centre; London Health Sciences Centre; University of Toronto; University Health Network; Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Internal medicine; Oncology; Placebo; Head and neck squamous-cell carcinoma; PTEN; Cancer; Gene signature; Progression-free survival; Gene expression; Head and neck cancer; Gene; Overall survival; Pathology; PI3K/AKT/mTOR pathway; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004538714,0.000467337,0.0009806523,0.0001764555,0.0002031138,0.0005451223,0.000174776,0.0003590055,0.001409023],"category_scores_gemma":[0.0004523913,0.0002441713,0.0005523929,0.0002410705,0.0003476193,0.0003522826,0.0002726938,0.0010178,0.0002514099],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004261335,"about_ca_system_score_gemma":0.0006236492,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003789531,"about_ca_topic_score_gemma":0.001214536,"domain_scores_codex":[0.9998374,0.00004858451,0.000007840208,0.00004476472,0.00002437486,0.00003696009],"domain_scores_gemma":[0.9996934,0.00005449371,0.00007223912,0.00002072059,0.00001512606,0.0001441183],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.6980531,0.01464682,0.1571672,0.0003948517,0.0010416,0.0002713844,0.0002429449,0.001465559,0.06425319,0.0001663699,0.001097481,0.06119949],"study_design_scores_gemma":[0.07263329,0.475559,0.4274829,0.00003517625,0.001902179,0.0005684177,0.0002777483,0.003335643,0.01421841,0.0003627615,0.003561232,0.0000631755],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990388,0.0002553987,0.00009449421,0.00004521886,0.00001324786,0.00009193101,0.0002016374,0.000004350237,0.0002548562],"genre_scores_gemma":[0.9985989,0.0001595409,0.0002764489,0.00009243132,0.00002206366,0.0001349875,0.0003531964,0.000002639328,0.0003599097],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001409023,"threshold_uncertainty_score":0.004713655,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05184242678341498,"score_gpt":0.3564143244076636,"score_spread":0.3045718976242486,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}