{"id":"W2604602013","doi":"10.1158/1557-3125.dnarepair16-pr10","title":"Abstract PR10: Ionizing radiation-induced tumorigenesis is associated with exome-wide mutational signatures conserved in mice and humans","year":2017,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Exome sequencing; Carcinogenesis; Cancer research; Biology; Germline; Germline mutation; Cancer; Exome; CDKN2A; Malignancy; Somatic cell; Mutation; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005108799,0.0001547336,0.0001667649,0.0001184291,0.0004179691,0.0002256717,0.0003017098,0.0001564942,0.00002952227],"category_scores_gemma":[0.0007277576,0.0001573384,0.00004347751,0.0001041254,0.0001794574,0.00001100439,0.000143411,0.0002562471,0.00000243922],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001216263,"about_ca_system_score_gemma":0.0005654157,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002406312,"about_ca_topic_score_gemma":0.004291668,"domain_scores_codex":[0.998483,0.00008214932,0.0001878213,0.0004753682,0.0003746674,0.0003970068],"domain_scores_gemma":[0.9989803,0.0001142292,0.0001237384,0.0003677999,0.0002996322,0.0001142455],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002502945,0.00008161287,0.04361939,0.00003504786,0.0001423815,0.0001795015,0.0002269177,0.0003893852,0.9525319,0.0001017987,0.001047836,0.001393947],"study_design_scores_gemma":[0.001510899,0.0001664848,0.4882573,0.00009838326,0.00001541899,0.000002649419,0.0000910832,0.00008023768,0.5081314,0.0002937217,0.001082516,0.0002698131],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949545,0.002838289,0.00002759185,0.001149174,0.00007543155,0.0003371587,0.00008155469,0.000005243469,0.0005310994],"genre_scores_gemma":[0.9985499,0.000557048,0.00005537657,0.0003447307,0.0001080841,0.0001390848,0.0000934264,0.00003598544,0.0001163736],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.444638,"threshold_uncertainty_score":0.6416075,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04335800615970592,"score_gpt":0.3492018640452662,"score_spread":0.3058438578855603,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}