{"id":"W2604615965","doi":"10.1158/1557-3125.dnarepair16-ia27","title":"Abstract IA27: Exploiting the inhibition of cullin-RING-ligases in DSB repair as a therapeutic strategy","year":2017,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Cullin; Ubiquitin; DNA repair protein XRCC4; DNA repair; Ubiquitin ligase; Ku70; Biology; Cell biology; Ku80; Non-homologous end joining; DNA damage; Camptothecin; Cancer research; DNA; Genetics; Biochemistry; DNA-binding protein; DNA mismatch repair; Transcription factor","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002283405,0.0006156655,0.0003920521,0.0004826848,0.0001592651,0.0004808875,0.0005377849,0.0003791905,0.002548367],"category_scores_gemma":[0.00008776841,0.0001284643,0.0003503195,0.0002889139,0.0003206545,0.0002863876,0.000279882,0.001070599,0.0009406261],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003502028,"about_ca_system_score_gemma":0.0003674876,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004570024,"about_ca_topic_score_gemma":0.0005516241,"domain_scores_codex":[0.9998972,0.00001487502,0.000008029707,0.00001744115,0.0000210723,0.00004134941],"domain_scores_gemma":[0.9999365,0.000004961819,0.00001369083,0.00000977667,0.000008520356,0.00002668365],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006595982,0.0004823685,0.0001755039,0.0003365396,0.00007210756,0.0002912324,0.00002786781,0.000867983,0.9692675,0.003214481,0.001797542,0.02280726],"study_design_scores_gemma":[0.0001583171,0.001689319,0.0007969363,0.00002980611,0.00009031,0.0004339283,0.00002874789,0.00149825,0.9701861,0.0003789708,0.02469615,0.00001316965],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.909865,0.03016377,0.02837262,0.001987514,0.0006710007,0.000563598,0.002037814,0.001170087,0.02516866],"genre_scores_gemma":[0.9749264,0.009017458,0.004306853,0.000258,0.00005404693,0.0001743239,0.0009516376,0.00005981013,0.01025143],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002548367,"threshold_uncertainty_score":0.008525133,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1053734536756551,"score_gpt":0.406474346622086,"score_spread":0.3011008929464309,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}