{"id":"W2604628994","doi":"10.1016/j.str.2017.03.006","title":"Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel","year":2017,"lang":"en","type":"article","venue":"Structure","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Lundbeckfonden; GlaxoSmithKline; Merck; Deutsche Forschungsgemeinschaft; Canada Foundation for Innovation; Novartis Foundation; Ontario Ministry of Economic Development and Innovation; Wellcome Trust; Genome Canada; AbbVie; Janssen Biotech; Wellcome; Biotechnology and Biological Sciences Research Council; Boehringer Ingelheim","keywords":"Biophysics; Chemistry; Bilayer; Crystallography; Biology; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007524505,0.0001977787,0.0001755444,0.00007301471,0.0003014788,0.000316519,0.0002282182,0.0002298494,0.001125143],"category_scores_gemma":[0.0003185336,0.0001635522,0.0001412865,0.00008100046,0.0003786121,0.0005813814,0.0002831395,0.0004053148,0.0001714513],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003348716,"about_ca_system_score_gemma":0.0003119043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008744036,"about_ca_topic_score_gemma":0.0009215992,"domain_scores_codex":[0.9999572,0.000005885582,0.000002739455,0.000008471722,0.00001036773,0.00001527304],"domain_scores_gemma":[0.999908,0.00002720859,0.00002689968,0.00000641303,0.00001001217,0.00002145853],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002633294,0.00005039394,0.001127027,0.00003679993,0.00001139717,0.0001016203,0.00006560772,0.009130844,0.9868878,0.000897034,0.00005567885,0.001372533],"study_design_scores_gemma":[0.0002346796,0.0003214567,0.01934673,0.0000182502,0.00003543502,0.0002477148,0.0003420138,0.2797821,0.6965196,0.002101895,0.0009680259,0.00008216276],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986059,0.00004200157,0.0009210758,0.00003770649,0.000004654445,0.000003054754,0.00002782408,0.00001931408,0.00033861],"genre_scores_gemma":[0.9994799,0.00007433413,0.0003194997,0.000008262301,0.000001204974,0.000004087609,0.00002546391,0.000008880503,0.00007844737],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001125143,"threshold_uncertainty_score":0.003764033,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007287218872519157,"score_gpt":0.2289954837495477,"score_spread":0.2217082648770286,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}