{"id":"W2604628994","doi":"10.1016/j.str.2017.03.006","title":"Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel","year":2017,"lang":"en","type":"article","venue":"Structure","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Lundbeckfonden; GlaxoSmithKline; Merck; Deutsche Forschungsgemeinschaft; Canada Foundation for Innovation; Novartis Foundation; Ontario Ministry of Economic Development and Innovation; Wellcome Trust; Genome Canada; AbbVie; Janssen Biotech; Wellcome; Biotechnology and Biological Sciences Research Council; Boehringer Ingelheim","keywords":"Biophysics; Chemistry; Bilayer; Crystallography; Biology; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000552551,0.0001273084,0.0001309292,0.00002304656,0.000390856,0.00002392748,0.0001919524,0.0001856837,0.00004501607],"category_scores_gemma":[0.0001046246,0.00008626436,0.0001282421,0.00003861232,0.0001503383,0.000007090332,0.00003855014,0.00009862857,0.000001101978],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007504948,"about_ca_system_score_gemma":0.00003947165,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001998567,"about_ca_topic_score_gemma":0.00008395444,"domain_scores_codex":[0.99933,0.00005729969,0.0001337737,0.0002006114,0.0001338528,0.0001444446],"domain_scores_gemma":[0.9991532,0.000006354267,0.0001686767,0.0005063765,0.0001208759,0.00004452571],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001040098,0.000006913102,0.0006119146,0.00001099724,0.00005339908,7.678467e-7,0.00009161756,0.0005148221,0.9972908,0.0003004601,0.0003550228,0.0006592195],"study_design_scores_gemma":[0.002483733,0.0001401929,0.1504842,0.00002023359,0.00006798645,0.00006068712,0.0001314735,0.005244358,0.8366368,0.00239415,0.002030845,0.0003053368],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948468,0.00003446392,0.001462555,0.001255438,0.00130513,0.0002268521,0.0005024825,0.00001069878,0.0003555728],"genre_scores_gemma":[0.9989647,0.000004060798,0.00002946064,0.0002032063,0.000439307,0.000003331464,0.0001162029,0.00001222152,0.0002274625],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1606541,"threshold_uncertainty_score":0.3517759,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007287218872519157,"score_gpt":0.2289954837495477,"score_spread":0.2217082648770286,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}