{"id":"W2604639310","doi":"10.1158/1557-3125.dnarepair16-pr16","title":"Abstract PR16: Normal and neoplastic tissues with partial Hus1 impairment show hypersensitivity to cisplatin in vivo","year":2017,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Cisplatin; DNA damage; In vivo; Cancer research; Oncogene; DNA repair; G2-M DNA damage checkpoint; Biology; Cancer; DNA; Cell cycle; Chemotherapy; Cell cycle checkpoint; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006233666,0.0001742211,0.0001778639,0.00009726996,0.0002315028,0.0001550753,0.0002607859,0.000118289,0.00004514923],"category_scores_gemma":[0.0001483187,0.0001607197,0.00003605,0.00007782137,0.0001734632,0.00001186625,0.0004069244,0.0002266416,0.0000109402],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005997235,"about_ca_system_score_gemma":0.0001939779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001140306,"about_ca_topic_score_gemma":0.002857007,"domain_scores_codex":[0.9981094,0.0001065958,0.0001418867,0.0005767859,0.0004751759,0.0005901447],"domain_scores_gemma":[0.998936,0.00001731054,0.00004819594,0.0006503331,0.0001226962,0.0002254786],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005176198,0.00006892334,0.004962492,0.00003795809,0.00003567521,0.0003794159,0.0001107043,0.0002486542,0.9894195,0.00004373562,0.0002122591,0.003963041],"study_design_scores_gemma":[0.0008137885,0.0007573774,0.01704306,0.00008300572,0.000007913439,0.00002330128,0.00007866239,0.0001806173,0.9771451,0.00002141181,0.003618232,0.0002275532],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969323,0.0001963755,0.0003351926,0.0005755835,0.0000599358,0.0005319198,0.00002762828,0.000009496258,0.001331558],"genre_scores_gemma":[0.9985991,0.00005207372,0.0006137312,0.00008356861,0.0001048762,0.0001702814,0.000006896505,0.00003506061,0.0003344067],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01227444,"threshold_uncertainty_score":0.6553959,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02591955597807204,"score_gpt":0.3453491980137439,"score_spread":0.3194296420356718,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}