{"id":"W2604639310","doi":"10.1158/1557-3125.dnarepair16-pr16","title":"Abstract PR16: Normal and neoplastic tissues with partial Hus1 impairment show hypersensitivity to cisplatin in vivo","year":2017,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Cisplatin; DNA damage; In vivo; Cancer research; Oncogene; DNA repair; G2-M DNA damage checkpoint; Biology; Cancer; DNA; Cell cycle; Chemotherapy; Cell cycle checkpoint; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002054364,0.0005284054,0.0003812356,0.0006613138,0.0001461661,0.0002561497,0.0002650897,0.0004122077,0.003907421],"category_scores_gemma":[0.0001470593,0.0003058518,0.0002978304,0.0002881042,0.000450912,0.0003047359,0.0002957831,0.000914152,0.0008694822],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002559879,"about_ca_system_score_gemma":0.000213766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005893281,"about_ca_topic_score_gemma":0.0008630744,"domain_scores_codex":[0.9996521,0.00003043145,0.00004479273,0.00009922246,0.000109775,0.00006368017],"domain_scores_gemma":[0.9995066,0.00004556873,0.0001840259,0.00004585851,0.00002720281,0.0001908489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002068131,0.00004073408,0.0002086597,0.00001948322,0.000005472905,0.00005456559,0.000008823084,0.0000342624,0.9990075,0.00003401214,0.00002309102,0.0003565443],"study_design_scores_gemma":[0.00004232244,0.001348991,0.01039655,0.000009346862,0.00002375272,0.001094159,0.00005869325,0.0005908931,0.9848038,0.00005072855,0.001573551,0.000007128813],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950878,0.000770522,0.001751743,0.0001035952,0.00003946342,0.000052466,0.001041546,0.0001215404,0.001031308],"genre_scores_gemma":[0.9876252,0.0005655455,0.002086422,0.00006694163,0.00001007167,0.00009585178,0.001248315,0.00006312125,0.008238588],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003907421,"threshold_uncertainty_score":0.0130716,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02591955597807204,"score_gpt":0.3453491980137439,"score_spread":0.3194296420356718,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}