{"id":"W2604665854","doi":"10.1158/1557-3125.dnarepair16-b30","title":"Abstract B30: Talazoparib efficacy is enhanced by noncytotoxic doses of temozolomide-mediated DNA damage in prostate cancer cell lines","year":2017,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"LNCaP; Prostate cancer; Cancer research; Enzalutamide; Olaparib; PARP inhibitor; Cancer; Cancer cell; Temozolomide; Poly ADP ribose polymerase; DNA damage; Chemistry; Molecular biology; Biology; Androgen receptor; Medicine; DNA; Internal medicine; Polymerase; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002548961,0.0005132503,0.0006441299,0.0004138261,0.0003002363,0.0004200826,0.0003134192,0.000429032,0.007945846],"category_scores_gemma":[0.0001295517,0.0001808138,0.0003570714,0.0005713906,0.0002510364,0.0002516542,0.0001802441,0.001132955,0.001085749],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00051927,"about_ca_system_score_gemma":0.0004743395,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0033957,"about_ca_topic_score_gemma":0.003588932,"domain_scores_codex":[0.9996,0.00007211157,0.00003402323,0.0000604369,0.0001512509,0.00008216542],"domain_scores_gemma":[0.9998791,0.000022203,0.00002318229,0.00001384699,0.00002852675,0.00003322135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001058361,0.0004699263,0.0003805712,0.0001713628,0.00003256684,0.00005676212,0.00003807668,0.000202127,0.9926104,0.0001093977,0.0009222136,0.003948239],"study_design_scores_gemma":[0.0001913783,0.0039378,0.01029068,0.000009284651,0.00004353743,0.0002278678,0.00005114844,0.0009865905,0.9806815,0.00003135444,0.003540568,0.000008362855],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9832278,0.002667759,0.00259509,0.00027866,0.00008519894,0.0001591317,0.003891551,0.0003485419,0.006746292],"genre_scores_gemma":[0.9861547,0.001163914,0.001722793,0.0001254152,0.00001731751,0.0001951346,0.004635988,0.00003136811,0.005953431],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007945846,"threshold_uncertainty_score":0.02658147,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05409114726025496,"score_gpt":0.4316400059492908,"score_spread":0.3775488586890359,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}