{"id":"W2604674371","doi":"10.1038/srep45788","title":"Efficacy of alirocumab according to background statin type and dose: pooled analysis of 8 ODYSSEY Phase 3 clinical trials","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Regeneron Pharmaceuticals; Sanofi","keywords":"Alirocumab; Rosuvastatin; Atorvastatin; Statin; PCSK9; Medicine; Simvastatin; Ezetimibe; Internal medicine; Placebo; Pharmacology; Urology; Cholesterol; Lipoprotein; LDL receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01417493,0.00167547,0.008820405,0.001319326,0.0002686296,0.001864012,0.0006250524,0.001058964,0.001824596],"category_scores_gemma":[0.01365072,0.0008784173,0.01704219,0.001631435,0.0004815386,0.00103331,0.001029936,0.001274047,0.0001996094],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007045003,"about_ca_system_score_gemma":0.0009645908,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009412788,"about_ca_topic_score_gemma":0.003468422,"domain_scores_codex":[0.9891347,0.007014225,0.0017268,0.001087544,0.0007496795,0.0002870421],"domain_scores_gemma":[0.9900585,0.005433354,0.002830746,0.0007570598,0.0006145867,0.0003058256],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.4270415,0.0001710427,0.01815346,0.0176869,0.5043583,0.00009464809,0.0001020975,0.001457777,0.002628552,0.00009756329,0.001123403,0.02708477],"study_design_scores_gemma":[0.1360714,0.0134871,0.0940415,0.001519974,0.7472299,0.0002646971,0.00009455674,0.002014637,0.001252121,0.0006613368,0.003232468,0.0001303037],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5968868,0.3870054,0.004417971,0.0007318296,0.0005053518,0.001625048,0.006053726,0.0002759137,0.002497937],"genre_scores_gemma":[0.9610499,0.03061931,0.002464235,0.0008262835,0.0002336203,0.001299168,0.002645258,0.00008252836,0.0007796914],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01417493,"threshold_uncertainty_score":0.07496506,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1702918624996737,"score_gpt":0.4937388170007613,"score_spread":0.3234469545010876,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}