{"id":"W2604684472","doi":"10.1182/blood.v128.22.1852.1852","title":"Biomarkers of Cytokine Release Syndrome and Neurotoxicity after CD19 CAR-T Cells and Mitigation of Toxicity By Cell Dose","year":2016,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Cytokine release syndrome; Medicine; CD8; Toxicity; CD19; Immunology; T cell; Internal medicine; Gastroenterology; Chimeric antigen receptor; Antigen; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004402452,0.0002216779,0.0002354429,0.0002492202,0.00008115292,0.0002276156,0.0001330492,0.000182211,0.0007690994],"category_scores_gemma":[0.0005810197,0.00008317681,0.0001468614,0.0001835047,0.0001495139,0.0001663668,0.000126133,0.0003547283,0.0001223667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000194582,"about_ca_system_score_gemma":0.0001391686,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000182246,"about_ca_topic_score_gemma":0.0002408977,"domain_scores_codex":[0.9997838,0.00007385523,0.00002167281,0.00002546733,0.00006810199,0.00002717524],"domain_scores_gemma":[0.9995254,0.0001000337,0.000243082,0.00002465369,0.00006065561,0.00004617755],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0106865,0.0006651735,0.5225388,0.0003205526,0.0001722884,0.0007867216,0.0002279947,0.001685556,0.3840835,0.0001700802,0.0005945819,0.07806827],"study_design_scores_gemma":[0.0002617033,0.02303657,0.5409997,0.00003907853,0.0003152937,0.003250603,0.0001433841,0.003944164,0.4255593,0.0001410233,0.002295868,0.00001335614],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997596,0.0009829128,0.0007550488,0.00002110546,0.00000401574,0.00004280253,0.00009034858,0.00001752327,0.000490216],"genre_scores_gemma":[0.9990452,0.0001449079,0.0003818574,0.00001748493,0.000004245214,0.00002957639,0.0001367451,0.000001647011,0.0002382185],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007690994,"threshold_uncertainty_score":0.002572954,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008121120329729692,"score_gpt":0.2371636937176329,"score_spread":0.2290425733879032,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}