{"id":"W2604694191","doi":"10.1158/1557-3125.dnarepair16-ia05","title":"Abstract IA05: Prospective identification of vulnerabilities to DNA repair inhibitors","year":2017,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"Biomedical Ethics and Regulation","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute","funders":"","keywords":"CRISPR; Computational biology; Identification (biology); Cancer; Biology; Cas9; DNA repair; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001239896,0.0003528821,0.0004903362,0.00137625,0.0005283356,0.001990473,0.0005016843,0.0009363055,0.007128296],"category_scores_gemma":[0.001902955,0.0001588313,0.0003203832,0.001125839,0.0007834776,0.0006547796,0.001098857,0.001129652,0.001832155],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001568059,"about_ca_system_score_gemma":0.001178201,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001363317,"about_ca_topic_score_gemma":0.001330654,"domain_scores_codex":[0.9992557,0.0001477256,0.00005630035,0.000144841,0.0002641681,0.0001311672],"domain_scores_gemma":[0.9987383,0.0002223778,0.0003171505,0.0001348088,0.0003461517,0.0002412091],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001443092,0.0005785569,0.1050925,0.001054363,0.0001220246,0.003709895,0.001315429,0.0008830604,0.3603495,0.08097951,0.08834927,0.3561227],"study_design_scores_gemma":[0.00006946283,0.001848925,0.1643305,0.0004338348,0.0002029354,0.01842234,0.002147946,0.002429128,0.2859494,0.02867025,0.4953725,0.0001226878],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7200788,0.02818016,0.02769805,0.02876002,0.001535013,0.0007135767,0.01359862,0.001302415,0.1781335],"genre_scores_gemma":[0.9261699,0.008993653,0.01992771,0.005366528,0.000215047,0.0001682613,0.006112386,0.00009634904,0.03295015],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007128296,"threshold_uncertainty_score":0.02384651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06371434667816447,"score_gpt":0.4417992085950929,"score_spread":0.3780848619169285,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}