{"id":"W2604718152","doi":"10.1128/mbio.00157-17","title":"The R263K Dolutegravir Resistance-Associated Substitution Progressively Decreases HIV-1 Integration","year":2017,"lang":"en","type":"article","venue":"mBio","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Government of Canada","keywords":"Dolutegravir; Integrase; Reverse transcriptase; Integrase inhibitor; Virology; Provirus; DNA; Biology; Virus; Jurkat cells; Viral load; Human immunodeficiency virus (HIV); Medicine; RNA; Genome; Antiretroviral therapy; Immunology; Genetics; Gene; Immune system; T cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001722659,0.0004256346,0.0004762654,0.0001316509,0.0001197009,0.0003238675,0.0003043352,0.0003589114,0.002642379],"category_scores_gemma":[0.0002530145,0.0001578526,0.0004159644,0.0001873369,0.0002731955,0.0001606803,0.00014922,0.00079956,0.001112766],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002029897,"about_ca_system_score_gemma":0.0001533535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004205662,"about_ca_topic_score_gemma":0.0003950512,"domain_scores_codex":[0.999761,0.00004907402,0.00002790059,0.00005318894,0.00006421301,0.00004455713],"domain_scores_gemma":[0.9998214,0.00003489471,0.0000632952,0.00003300231,0.00001762347,0.00002983678],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003243868,0.0000951919,0.0004001578,0.00002935943,0.00001329607,0.00005980745,0.000008934766,0.0001352569,0.9966034,0.0000403988,0.00007190597,0.002217867],"study_design_scores_gemma":[0.00006956706,0.002278919,0.007534392,0.00001158784,0.00003923761,0.001426865,0.00003675227,0.002031432,0.9835271,0.00005925769,0.002966386,0.0000184195],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997079,0.0004850068,0.001081623,0.00006983538,0.00002031333,0.00002182889,0.0004679462,0.00008657642,0.0006878597],"genre_scores_gemma":[0.9951504,0.0003000248,0.001978153,0.00007756006,0.000008176227,0.00001826667,0.000686708,0.00005491068,0.001725689],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002642379,"threshold_uncertainty_score":0.008839667,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02246594355290094,"score_gpt":0.288564956901137,"score_spread":0.266099013348236,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}