{"id":"W2604718152","doi":"10.1128/mbio.00157-17","title":"The R263K Dolutegravir Resistance-Associated Substitution Progressively Decreases HIV-1 Integration","year":2017,"lang":"en","type":"article","venue":"mBio","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Government of Canada","keywords":"Dolutegravir; Integrase; Reverse transcriptase; Integrase inhibitor; Virology; Provirus; DNA; Biology; Virus; Jurkat cells; Viral load; Human immunodeficiency virus (HIV); Medicine; RNA; Genome; Antiretroviral therapy; Immunology; Genetics; Gene; Immune system; T cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002417001,0.0001135317,0.0001176287,0.00002670484,0.002261332,0.0001565624,0.0003196649,0.0001253901,0.0001082099],"category_scores_gemma":[0.0007194108,0.00006735222,0.00006695687,0.00003599261,0.0005250031,0.0001193645,0.00005494353,0.0001775888,0.001541105],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001078862,"about_ca_system_score_gemma":0.00009872606,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000209074,"about_ca_topic_score_gemma":0.002143183,"domain_scores_codex":[0.9991304,0.0001544252,0.0001383292,0.0001918715,0.00005030663,0.0003346846],"domain_scores_gemma":[0.9991663,0.0001076361,0.0001524838,0.0004342462,0.0001101887,0.00002917076],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.003824404,0.002272882,0.1964703,0.00003605891,0.002287973,0.0002845711,0.001300676,7.85172e-7,0.1582665,0.07568988,0.3514688,0.2080972],"study_design_scores_gemma":[0.003530372,0.0002595547,0.6420867,0.0001780235,0.00008222214,0.00001645554,0.0002978212,0.000003025842,0.08544119,0.00199418,0.2658359,0.0002745392],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9741818,0.006386912,0.000122251,0.003214112,0.0006195055,0.0006463116,0.0002440321,0.0001229435,0.0144621],"genre_scores_gemma":[0.9822826,0.0002296805,0.00003232927,0.00001410654,0.00002172721,0.00009386068,0.0005076518,0.000006678551,0.0168114],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4456164,"threshold_uncertainty_score":0.9992363,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02246594355290094,"score_gpt":0.288564956901137,"score_spread":0.266099013348236,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}