{"id":"W2604729247","doi":"10.1007/s11010-017-3018-9","title":"Effect of empagliflozin on cardiac biomarkers in a zebrafish model of heart failure: clues to the EMPA-REG OUTCOME trial?","year":2017,"lang":"en","type":"article","venue":"Molecular and Cellular Biochemistry","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":74,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Michael's Hospital; University of Toronto","funders":"China Scholarship Council; Canada Foundation for Innovation; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Heart and Stroke Foundation of Canada","keywords":"Empagliflozin; EMPA; Zebrafish; Heart failure; Internal medicine; Medicine; Clinical chemistry; Cardiology; Chemistry; Diabetes mellitus; Endocrinology; Type 2 diabetes; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001482876,0.0005867581,0.001146664,0.0001615828,0.0001953619,0.0006765526,0.0003180366,0.001051111,0.001911204],"category_scores_gemma":[0.0005681731,0.0001178021,0.0009858726,0.0001501387,0.0006183697,0.0005802573,0.0002374385,0.002236017,0.0002768409],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004635087,"about_ca_system_score_gemma":0.0006809803,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000631489,"about_ca_topic_score_gemma":0.001919178,"domain_scores_codex":[0.9998553,0.00005083533,0.00001157687,0.00002437167,0.00002149795,0.0000365274],"domain_scores_gemma":[0.9997739,0.00003343984,0.00005691347,0.00003057034,0.00002277847,0.0000823348],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.3547696,0.01307836,0.007235178,0.00243087,0.003414753,0.0006273243,0.0001548531,0.001935212,0.1877279,0.004906817,0.02111599,0.4026031],"study_design_scores_gemma":[0.3380933,0.4152412,0.06714376,0.001153111,0.008930069,0.0007550681,0.0005305849,0.004539456,0.09951846,0.006472539,0.05730654,0.0003158443],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9559107,0.0212079,0.001833773,0.01319902,0.001053569,0.0003522506,0.001290589,0.0002279955,0.004924101],"genre_scores_gemma":[0.9768092,0.01093404,0.00220501,0.004138287,0.0003723897,0.000518126,0.0007812426,0.00003271654,0.004209003],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001911204,"threshold_uncertainty_score":0.007842302,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009930754074494398,"score_gpt":0.267138505099183,"score_spread":0.2572077510246886,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}