{"id":"W2604744033","doi":"10.1021/acs.jmedchem.6b01781","title":"A “Click Chemistry Platform” for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation","year":2017,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":204,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"","keywords":"Linker; Bromodomain; Ubiquitin ligase; Chemistry; Ubiquitin; DNA ligase; Protein degradation; Target protein; Click chemistry; Ternary complex; Proteolysis; Native chemical ligation; Small molecule; Biochemistry; Ubiquitin-Protein Ligases; Cell biology; Combinatorial chemistry; Chemical synthesis; DNA; Biology; Enzyme; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008135929,0.0001598549,0.0002622082,0.00001927646,0.0002530072,0.000041585,0.0005849361,0.0001941151,0.00003783911],"category_scores_gemma":[0.003037228,0.000111833,0.0002563277,0.00002937219,0.0001925689,0.00001747875,0.00005516158,0.0001683937,2.007023e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002846139,"about_ca_system_score_gemma":0.0002214118,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004401738,"about_ca_topic_score_gemma":7.69939e-7,"domain_scores_codex":[0.9988058,0.00001127963,0.0005385084,0.0001776869,0.0002822166,0.0001845457],"domain_scores_gemma":[0.9977333,0.0001008765,0.001215505,0.0004545182,0.0004019763,0.00009380087],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004652149,0.00004612495,0.00004896329,0.0002896934,0.000111074,0.000001230813,0.00001813892,0.000006253967,0.9776391,0.000009355211,0.002362336,0.01900254],"study_design_scores_gemma":[0.001048949,0.0001590028,0.0001119111,0.0002803855,0.00008685314,0.00005898587,0.0002962833,0.0001111176,0.9800857,0.00007736962,0.0175656,0.000117808],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.980248,0.002107855,0.01411935,0.00174194,0.0002020602,0.0005374607,0.00005099216,0.000004636785,0.0009877257],"genre_scores_gemma":[0.9953063,0.0001812916,0.002521453,0.00004172192,0.001270036,0.00008056527,0.0000233449,0.0000230976,0.0005522119],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01888473,"threshold_uncertainty_score":0.4560416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02649876102437507,"score_gpt":0.2790411026217938,"score_spread":0.2525423415974187,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}