{"id":"W2604744033","doi":"10.1021/acs.jmedchem.6b01781","title":"A “Click Chemistry Platform” for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation","year":2017,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":204,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"","keywords":"Linker; Bromodomain; Ubiquitin ligase; Chemistry; Ubiquitin; DNA ligase; Protein degradation; Target protein; Click chemistry; Ternary complex; Proteolysis; Native chemical ligation; Small molecule; Biochemistry; Ubiquitin-Protein Ligases; Cell biology; Combinatorial chemistry; Chemical synthesis; DNA; Biology; Enzyme; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004170819,0.0006863317,0.0002614258,0.0003678814,0.0001911172,0.0002749169,0.0004769821,0.0005597443,0.002262618],"category_scores_gemma":[0.0002536038,0.0003072218,0.0003946324,0.0002363252,0.0002774135,0.0005545343,0.0003095342,0.0008367423,0.001063959],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003541639,"about_ca_system_score_gemma":0.0002706502,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002306892,"about_ca_topic_score_gemma":0.0003942679,"domain_scores_codex":[0.9997534,0.00004253203,0.00001657409,0.00006447251,0.00008402034,0.00003895581],"domain_scores_gemma":[0.999878,0.0000255841,0.0000407812,0.00001704964,0.00001297349,0.00002551986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008263726,0.0000525561,0.00005151073,0.00008421114,0.00001203761,0.00008735254,0.00001236077,0.0002033715,0.9920815,0.0007718207,0.0003342991,0.006226202],"study_design_scores_gemma":[0.00001825597,0.0002854288,0.000215494,0.000002943104,0.00001214112,0.000310081,0.000002755876,0.0009036082,0.9917262,0.00008051135,0.006431642,0.00001099714],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6146052,0.007871475,0.3549159,0.0008562143,0.0004644431,0.0008839306,0.001898464,0.004501288,0.01400308],"genre_scores_gemma":[0.8509336,0.003675628,0.1305148,0.0004813382,0.0000866734,0.000446888,0.00147267,0.0001443984,0.01224414],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002262618,"threshold_uncertainty_score":0.007569253,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02649876102437507,"score_gpt":0.2790411026217938,"score_spread":0.2525423415974187,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}